A multicenter phase II study of preoperative chemoradiotherapy with S-1 plus oxaliplatin for locally advanced rectal cancer (SHOGUN trial)

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Satoshi MatsusakaToshiaki Watanabe

Abstract

This study was designed to evaluate the safety and efficacy of adding oxaliplatin to preoperative chemoradiotherapy (CRT) with S-1 in patients with locally advanced rectal carcinoma (LARC). This was a multicenter phase II study in patients with histologically proven clinical stage T3 or T4 (any N, M0) LARC. Patients preoperatively received oral S-1 (80 mg/m(2)/day on days 1-5, 8-12, 22-27, and 29-33) and infusional oxaliplatin (60 mg/m(2) days on 1, 8, 22, and 29) plus radiotherapy (50.4 Gy), with a chemotherapy gap in the third week of radiotherapy. Pathological complete response (pCR) was the primary endpoint. Secondary endpoints included toxicity, compliance, R0 resection rate, and downstaging rate. A total of 45 patients were enrolled at six centers in Japan. All 45 patients received CRT, and 44 underwent operation. A pCR was achieved in 12 (27.3%) of the 44 patients who underwent surgery. Near-total tumor regression was confirmed in 47.7%. There were no grade 4 adverse events, and 11.1% of the patients had grade 3 adverse events. R0 resection was achieved in 95.5% of the patients. Preoperative CRT with S-1 plus oxaliplatin had a high pCR rate and a favorable toxicity profile.

References

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Citations

Jul 5, 2019·Acta Oncologica·Bruce D Minsky
Jul 10, 2019·Molecular and Clinical Oncology·Takeshi NishikawaSoichiro Ishihara
May 25, 2018·Journal of the Anus, Rectum and Colon·Naohito BeppuNaohiro Tomita
May 25, 2018·Journal of the Anus, Rectum and Colon·Kazushige KawaiToshiaki Watanabe
Feb 3, 2021·International Journal of Colorectal Disease·Hajime MorohashiKenichi Hakamada
Apr 22, 2019·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Keisaku KondoToshifusa Nakajima

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