A multicenter phase II study of the combination of irinotecan and gemcitabine in previously treated patients with small-cell lung cancer

Oncology
Sofia AgelakiLung Cancer Subgroup, Hellenic Oncology Research Group

Abstract

To evaluate efficacy and toxicity of the combination of irinotecan and gemcitabine in pretreated patients having small-cell lung cancer. Thirty-one patients (median age 60 years, performance status 0-1 in 87% and 2 in 13% of the patients) with limited or extensive-stage disease, refractory or relapsing after at least one prior chemotherapy regimen, received gemcitabine 1,000 mg/m(2) on days 1 and 8 and irinotecan 300 mg/m(2) on day 8, every 21 days. Sixteen (52%) patients had sensitive and 15 (48%) refractory disease. Fifteen patients (48%) had received > or =2 prior regimens. All patients were evaluable for toxicity and 26 for response analysis. A median of three (range 1-6) cycles per patient was administered. Three partial responses were documented for an overall response rate of 10% (95% CI 0.73-20.09), and disease stabilization was obtained in 7 patients (22%; intention-to-treat analysis). Two of the responders had refractory, and 1 had sensitive disease. The median time to progression was 4.5 months, the median duration of responses was 2.5 months, and the median survival time was 6 months. Grade 3-4 (WHO) neutropenia was observed in 9 patients (29%), grade 3-4 thrombocytopenia in 4 (13%), and grade 3-4 diahrrea in 3 pati...Continue Reading

Citations

May 8, 2007·Cancer Chemotherapy and Pharmacology·Fumiyoshi OhyanagiMakoto Nishio
Feb 1, 2007·Anti-cancer Drugs·Hatem A Azim, Apar Kishor Ganti
Sep 1, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Marcello Tiseo, Andrea Ardizzoni
Dec 23, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Athanasios G PallisVassilis Georgoulias
Oct 29, 2008·Clinical Lung Cancer·Jeffrey Allen, Mohammad Jahanzeb
Aug 30, 2017·Expert Review of Anticancer Therapy·Nathalie BaizeChristos Chouaid

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