A multicenter, randomized, blind comparison of amrinone with milrinone after elective cardiac surgery

Anesthesia and Analgesia
J P RathmellR L Royster

Abstract

Amrinone and milrinone are phosphodiesterase inhibitors with positive inotropic effects useful for the treatment of ventricular dysfunction after cardiac surgery. Forty-four patients undergoing elective cardiac surgery at four centers received either amrinone (n = 22) or milrinone (n = 22) in a randomized, blind fashion. Immediately after separation from cardiopulmonary bypass (CPB), two bolus doses of either amrinone 0.75 mg/kg or milrinone 25 microg/kg were administered over 30 s, separated by 5 min. Hemodynamic measurements were recorded before each dose and at the end of the 10-min study. Both amrinone and milrinone increased the cardiac index (48% vs 52%, P = not significant [NS] for amrinone and milrinone, respectively). There was a small increase in mean arterial pressure (MAP) after amrinone administration (from 68 +/- 3 to 72 +/- 3 mm Hg at 10 min, P < 0.05) with no significant change in MAP after milrinone administration. Central venous pressure was significantly higher in the amrinone group at baseline and 5 min (12 vs 10 mm Hg and 11 vs 10 mm Hg, respectively; P < 0.05). Systemic and pulmonary vascular resistances decreased significantly and to a similar extent after either amrinone or milrinone administration. Phen...Continue Reading

References

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Citations

Feb 23, 2002·Current Treatment Options in Cardiovascular Medicine·Linda L. Liu, Michael A. Gropper
Apr 3, 2007·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Georg Delle KarthGottfried Heinz
Oct 16, 2012·Journal of Cardiothoracic and Vascular Anesthesia·David T MajureGiovanni Landoni
Mar 27, 2012·Medicina intensiva·J L Pérez VelaUNKNOWN Grupo de Trabajo de Cuidados Intensivos Cardiológicos y RCP de SEMICYUC, con el aval científico de la SEMICYUC
Mar 27, 2012·Medicina intensiva·J L Pérez VelaUNKNOWN Grupo de Trabajo de Cuidados Intensivos Cardiológicos y RCP de SEMICYUC, con el aval científico de la SEMICYUC
Sep 29, 2011·Journal of Cardiothoracic and Vascular Anesthesia·Alberto ZangrilloGiovanni Landoni
Mar 8, 2011·Journal of Cardiothoracic and Vascular Anesthesia·Maqsood M ElahiBashir M Matata
Mar 20, 2015·Acta Anaesthesiologica Scandinavica·F ZoernerE Semenas
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Mar 20, 2001·Journal of Cardiothoracic and Vascular Anesthesia·M J Griffin, R L Hines
Jan 4, 2007·Seminars in Cardiothoracic and Vascular Anesthesia·André Y DenaultLouis P Perrault

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