A multicenter randomized clinical trial of etonogestrel and levonorgestrel contraceptive implants with nonrandomized copper intrauterine device controls: effect on weight variations up to 3 years after placement

Contraception
Luis BahamondesWHO Study Group on Contraceptive Implants for Women

Abstract

To evaluate weight changes in women randomized to either the etonogestrel (ENG)- or the levonorgestrel (LNG)-releasing contraceptive implants and to compare with users of the TCu380A intrauterine device (IUD). A multicenter randomized trial with 1:1 allocation ratio of the ENG and the LNG implants with nonrandomized, age-matched control group of women choosing TCu380A IUD. The primary objective was to assess contraceptive efficacy and method continuation rates and, secondarily, the incidence of common complaints and side effects (including weight changes) associated with use of the three contraceptives. All women were enrolled in nine centers at seven countries. Weight change was evaluated from time at device(s) placement. Confounders were sociodemographic, baseline weight and body mass index, center and time from insertion. We used a linear mixed-effects regression modeling with random intercept and slope. Weight was compared between the two implants groups and between the implants and the IUD groups through linear mixed multivariable regression model. A total of 995, 997 and 971 users in the ENG implant, LNG implant and IUD groups, respectively, were included. At 36 months of use, ENG and LNG implant users had similar signifi...Continue Reading

References

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Jan 4, 2017·Contraception·Priscilla de Nazaré Silva Dos SantosJeffrey F Peipert

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Citations

Jul 22, 2020·Current Opinion in Pediatrics·Alexandra J EdwardsSarah Pitts
Feb 18, 2021·BMJ Sexual & Reproductive Health
Apr 1, 2019·Journal of Pediatric and Adolescent Gynecology·Mary E Romano, Debra K Braun-Courville
Mar 24, 2021·Reproductive Biology and Endocrinology : RB&E·Heather C M AllawaySusan A Bloomfield
Jul 6, 2020·Journal of Pediatric and Adolescent Gynecology·Elise D BerlanDiana Mansour
Jul 3, 2021·Pharmaceuticals·Morena Luigia RoccaCostantino Di Carlo
Aug 15, 2021·Journal of Pediatric and Adolescent Gynecology·Nadia ScottSusan M Coupey
Dec 24, 2021·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Giulia FredericoArlete Fernandes

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