PMID: 12766654May 27, 2003Paper

A multicenter, randomized, controlled trial comparing bupivacaine with ropivacaine for labor analgesia

Anesthesiology
S HalpernGordon H Fick

Abstract

A meta-analysis of studies comparing high doses of bupivacaine with ropivacaine for labor pain found a higher incidence of forceps deliveries, motor block, and poorer neonatal outcome with bupivacaine. The purpose of this study was to determine if there is a difference in these outcomes when a low concentration of patient-controlled epidural bupivacaine combined with fentanyl is compared with ropivacaine combined with fentanyl. This was a multicenter, randomized, controlled trial, including term, nulliparous women undergoing induction of labor. For the initiation of analgesia, patients were randomized to receive either 15 ml bupivacaine, 0.1%, or 15 ml ropivacaine, 0.1%, each with 5 microg/ml fentanyl. Analgesia was maintained with patient-controlled analgesia with either local anesthetic, 0.08%, with 2 microg/ml fentanyl. The primary outcome was the incidence of operative delivery. We also examined other obstetric, neonatal, and analgesic outcomes. There was no difference in the incidence of operative delivery between the two groups (148 of 276 bupivacaine recipients vs. 135 of 279 ropivacaine recipients; P = 0.25) or any obstetric or neonatal outcome. The incidence of motor block was significantly increased in the bupivacaine...Continue Reading

References

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Citations

Mar 17, 2010·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Pamela AngleDavid Streiner
Mar 30, 2005·International Journal of Obstetric Anesthesia·L C Tsen
Jan 12, 2007·International Anesthesiology Clinics·Richard M Smiley, Leroi Stephenson
Aug 25, 2007·Anesthesia and Analgesia·Yaakov BeilinCarol A Bodian
Feb 20, 2009·Anesthesia and Analgesia·Stephen H Halpern, Brendan Carvalho
Jun 10, 2010·Anesthesia and Analgesia·Yaakov Beilin, Stephen Halpern
Jan 1, 2010·Local and Regional Anesthesia·Marcos Silva, Stephen H Halpern
Dec 23, 2004·Paediatric Drugs·Giorgio Capogna, Michela Camorcia
Jul 11, 2008·British Journal of Anaesthesia·P V Waikar, R Wadsworth
Mar 15, 2006·Current Opinion in Anaesthesiology·Stephen Halpern
Apr 29, 2014·Taiwanese Journal of Obstetrics & Gynecology·Shin-Yan ChenLi-Kuei Chen
Nov 30, 2006·Pain Practice : the Official Journal of World Institute of Pain·Jack D Schim, Paul Stang
Apr 22, 2006·Annales Françaises D'anesthèsie Et De Rèanimation·E Lopard
Feb 21, 2006·International Journal of Obstetric Anesthesia·M O Columb, R D'Angelo
Aug 8, 2018·The Journal of Obstetrics and Gynaecology Research·Yang ZhangLiang-Tu Hui

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