A multicenter, randomized, investigator-blinded study of 5- and 10-day gatifloxacin versus 10-day amoxicillin/clavulanate in patients with acute bacterial sinusitis

Clinical Therapeutics
Lawrence D SherPhillip F Pierce

Abstract

Treatment guidelines for acute bacterial sinusitis recommend 10 to 14 days of therapy with amoxicillin/clavulanate, high-dose amoxicillin, cefpodoxime, cefuroxime, or a newer fluoroquinolone. This study compared the clinical efficacy of short-course (5-day) gatifloxacin with standard 10-day regimens of amoxicillin/clavulanate or gatifloxacin in patients with a diagnosis of acute, uncomplicated maxillary sinusitis. This was a multicenter, investigator-blinded study in adult patients (age >18 years) with physical findings, signs and symptoms (for at least 7 days), and radiographic findings indicating acute, uncomplicated maxillary sinusitis. Patients were randomized to receive gatifloxacin 400 mg once daily for 5 days, gatifloxacin 400 mg once daily for 10 days, or amoxicillin/clavulanate 875 mg twice daily for 10 days. Clinical response was assessed once between days 3 and 5 of treatment, once I to 3 days after the completion of study treatment, once 7 to 14 days posttreatment (test-of-cure visit), and once 21 to 28 days posttreatment. Safety was assessed throughout the study. The study enrolled 445 patients. The treatment groups were similar in terms of history of sinusitis, presenting signs and symptoms, and radiographic findi...Continue Reading

References

Oct 9, 1975·The New England Journal of Medicine·F O EvansJ M Gwaltney
Jan 6, 1994·The New England Journal of Medicine·J M GwaltneyD K Riker
Oct 23, 1997·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·S J Zinreich
Dec 11, 1997·Journal of Clinical Epidemiology·H ReyesG Gutiérrez
Sep 17, 1998·The Journal of Antimicrobial Chemotherapy·B P GoldsteinR Novick
Nov 3, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G V DoernR N Jones
Mar 9, 1999·The Journal of Allergy and Clinical Immunology·N F RayY H Pung
Nov 7, 1999·Drugs·C M PerryH M Lamb
Jul 11, 2000·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Apr 26, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D J HobanR N Jones

❮ Previous
Next ❯

Citations

Sep 15, 2004·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Berrylin J FergusonJames A Hadley
May 25, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Paul G AmbroseRonald N Jones
Jun 9, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jack B Anon
Oct 6, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Richard Frothingham
Feb 3, 2006·International Journal of Clinical Practice·M DesrosiersM Benninger
Jun 7, 2007·Postgraduate Medical Journal·Ajmal MasoodJaan Panesar
Feb 12, 2011·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Martin DesrosiersIan J Witterick
Mar 26, 2008·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Drosos E KarageorgopoulosMatthew E Falagas
Dec 21, 2004·Treatments in Respiratory Medicine·Wolfgang Elies, Kora Huber
May 14, 2010·International Journal of Antimicrobial Agents·Matthew E FalagasIlias I Siempos
Feb 13, 2007·Diagnostic Microbiology and Infectious Disease·James A Hadley, Michael A Pfaller
Dec 23, 2003·Journal of Internal Medicine·V OjettiA Gasbarrini
Jul 5, 2005·The American Journal of Medicine·Thomas G SlamaUNKNOWN Council for Appropriate and Rational Antibiotic Therapy (CARAT)
Jul 5, 2005·The American Journal of Medicine·Michael D Poole, Louis G Portugal
Aug 17, 2004·Infectious Disease Clinics of North America·Judith A O'Donnell, Steven P Gelone
Jul 22, 2014·Auris, Nasus, Larynx·Noboru YamanakaUNKNOWN Drafting Committee for Acute Rhinosinusitis Management Guideline, Japanese Rhinologic Society
Oct 17, 2015·The Cochrane Database of Systematic Reviews·Anneli Ahovuo-SalorantaMarjukka Mäkelä
Feb 13, 2003·Current Opinion in Allergy and Clinical Immunology·Samantha M Mucha, Fuad M Baroody

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.