A multicenter randomized trial of personalized acupuncture, fixed acupuncture, letrozole, and placebo letrozole on live birth in infertile women with polycystic ovary syndrome

Trials
Shiya HuangJie Qiao

Abstract

Traditional Chinese medicine (TCM) usually involves syndrome differentiation and treatment. Acupuncture, one form of TCM, requires the selection of appropriate acupoints and needling techniques, but many clinical trials on acupuncture have used fixed acupuncture protocols without accounting for individual patient differences. We have designed a multicenter randomized controlled trial (RCT) to evaluate whether personalized or fixed acupuncture increases the likelihood of live births in infertile women with polycystic ovary syndrome (PCOS) compared with letrozole or placebo letrozole. We hypothesize that letrozole is more effective than personalized acupuncture, which in turn is more effective than fixed acupuncture, and that placebo letrozole is the least effective intervention. Moreover, we hypothesize that personalized acupuncture is more likely to reduce the miscarriage rate and the risk of pregnancy complications compared with letrozole. The study is designed as an assessor-blinded RCT. A total of 1100 infertile women with PCOS will be recruited from 28 hospitals and randomly allocated to 4 groups: personalized acupuncture, fixed acupuncture, letrozole, or placebo letrozole. They will receive treatment for 16 weeks, and the ...Continue Reading

References

Jan 13, 2004·Human Reproduction Update·Adam H BalenDidier Dewailly
Sep 24, 2004·Best Practice & Research. Clinical Obstetrics & Gynaecology·Roy Homburg
Mar 1, 2008·Human Reproduction·UNKNOWN Thessaloniki ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group
May 13, 2009·Archives of Internal Medicine·Daniel C CherkinRichard A Deyo
Nov 26, 2009·Human Reproduction Update·Trevor G CooperKirsten M Vogelsong
Mar 25, 2010·BMJ : British Medical Journal·David MoherDouglas G Altman
Oct 12, 2010·The Journal of Clinical Endocrinology and Metabolism·Eszter VankySven Magnus Carlsen
Oct 15, 2010·American Journal of Physiology. Endocrinology and Metabolism·Elizabeth JedelElisabet Stener-Victorin
Jul 5, 2011·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Kun Hyung KimSun Mi Choi
Jul 19, 2011·Fertility and Sterility·Xiaomiao ZhaoDongzi Yang
Aug 6, 2011·The Journal of Clinical Endocrinology and Metabolism·Lisa M PastoreJames T Patrie
Jan 9, 2013·Annals of Internal Medicine·An-Wen ChanDavid Moher
Mar 14, 2013·American Journal of Physiology. Endocrinology and Metabolism·Julia JohanssonElisabet Stener-Victorin
May 17, 2013·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Yan-Hua ZhengHong-Xia Ma
May 28, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Gur KreindlerElad Schiff
Jul 10, 2014·The New England Journal of Medicine·Richard S LegroUNKNOWN NICHD Reproductive Medicine Network
Jun 29, 2015·Human Reproduction Update·Stefano PalombaBart C J M Fauser
Jun 24, 2016·Fertility and Sterility·Xiao-Ke WuUNKNOWN Reproductive and Developmental Network in Chinese Medicine
Oct 13, 2016·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Seok-Jae KoJae-Woo Park
Apr 14, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anna BenrickElisabet Stener-Victorin
Jun 28, 2017·JAMA : the Journal of the American Medical Association·Xiao-Ke WuUNKNOWN PCOSAct Study Group
Jan 20, 2019·Chinese Journal of Integrative Medicine·Hai-Yong Chen, Nong-Yu Liu
Aug 25, 2019·Complementary Therapies in Clinical Practice·Liqun WuWei Yi

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