A multicenter real-life study of the efficacy of an alpha-blocker with or without anticholinergic agent (imidafenacin) treatment in patients with lower urinary tract symptoms/benign prostatic hyperplasia and storage symptoms

International Journal of Clinical Practice
Seok ChoYoung Ho Kim

Abstract

To evaluate the efficacy and safety of combination therapy comprising a short-acting anticholinergic, imidafenacin and an alpha-blocker compared with monotherapy with an alpha-blocker only in men with lower urinary tract symptoms (LUTS) and storage symptoms. The 12-week, prospective, double-blind, randomised trial enrolled men with LUTS and storage symptom. The inclusion criteria were a total International Prostate Symptom Score (IPSS) ≥12, an IPSS question 4 score ≥2, ≥8 micturitions in 24 hours, and a prostate volume >20 mL. The primary outcome was a change in the micturition number from baseline. Bladder diary variables, Patient Perception of Intensity of Urgency Scale (PPIUS) scores, IPSS and safety were assessed. Of 260 patients screened, 221 completed the study. Patients were randomly assigned to receive an alpha-blocker only (n=111, group 1) or combination therapy comprising an alpha-blocker and an anticholinergic (n=110, group 2) for 12 weeks. Group 1 and 2 showed significant improvement in their 24-hour micturition numbers (-1.87 and -2.08, respectively), nocturia episodes (-0.48 and -0.53, respectively), total IPSS (-9.9 and -8.8, respectively), and PPIUS scores (-0.19 and -0.24, respectively). Micturition number per ...Continue Reading

References

Sep 23, 2003·Current Urology Reports·Jeffrey P Weiss, Jerry G Blaivas
Sep 27, 2003·Urologia Internationalis·Shigetaka MurakamiShoichi Ueda
Nov 16, 2006·JAMA : the Journal of the American Medical Association·Steven A KaplanZhonghong Guan
Apr 7, 2007·Nature Clinical Practice. Urology·Gary E Lemack
Apr 25, 2009·International Journal of Urology : Official Journal of the Japanese Urological Association·Yukio HommaUNKNOWN Imidafenacin Study Group
Jul 27, 2012·Urologia Internationalis·Naoki WadaHidehiro Kakizaki
May 29, 2014·Korean journal of urology·Hakmin Lee, Seong Jin Jeong

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Citations

Feb 13, 2018·Current Opinion in Urology·Alex GomelskyDavid C Dalton

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