A multicenter retrospective evaluation of Chronic Myeloid Leukemia (CML) therapy in Austria assessing the impact of early treatment response on patient outcomes in a real-life setting : R-EFECT study

Wiener klinische Wochenschrift
Andreas L PetzerPeter Valent

Abstract

Several clinical trials in chronic phase (CP) chronic myeloid leukemia (CML) showed that early response to tyrosine kinase inhibitor (TKI) treatment results in an improved long-term survival and progression-free survival. This study assessed whether patients achieving early treatment response (ETR; partial cytogenetic response or BCR-ABL1 mRNA ≤10% at 3 months) in daily practice also have a long-term survival benefit. The Retrospective Evaluation of Early response in CML for long-term Treatment outcome (R-EFECT), a multicenter, retrospective chart review, documented patients with newly diagnosed CML-CP starting first-line TKI therapy in routine clinical practice. The primary aim was to assess the 5‑year overall survival rate. Of the 211 patients from 12 centers across Austria (January 2004-May 2010), 176 (median age, 56 years) were included in the analysis. All patients received first-line therapy with imatinib. Overall, 136 patients (77.3%) achieved ETR (ETR+ group), whereas 40 (22.7%) did not reach ETR (ETR- group). The ETR+ group had higher 5‑year overall survival (92.5% vs. 77.5%, P = 0.018) and progression-free survival (95.6% vs. 87.5%, P = 0.06) rates compared with the ETR- group. As expected, more patients in the ETR- g...Continue Reading

References

Sep 10, 2011·Critical Reviews in Oncology/hematology·Peter ValentDominik Wolf
Nov 10, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David MarinLetizia Foroni
Apr 29, 2015·Blood·Susanne SausseleUNKNOWN Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung and the German CML Study Group
May 25, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jorge E CortesAndreas Hochhaus
Nov 2, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jorge E CortesTim H Brümmendorf

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