A multicenter study evaluating the sensitization potential of enamel matrix derivative after treatment of two infrabony defects

Journal of Periodontology
Stuart FroumCharles Wagener

Abstract

Several studies reported some success toward regeneration in infrabony defects using enamel matrix derivative (EMD). Clinically and statistically significant improvements in probing depth reduction, clinical attachment levels, and bone fill have been demonstrated. This multi-center study evaluated the potential for sensitization to EMD in a subgroup of periodontal patients treated at least twice with at least 2 months between treatments. Three hundred seventy-six (376) patients in 11 university-based postgraduate periodontics programs and five private practices were selected. Surgeries were performed on infrabony defects. Following reflection of mucoperiosteal flaps and debridement of the root surface and defect, root conditioning (either citric acid pH = 1 or 24% EDTA) was performed and the site was irrigated with sterile saline. Enamel matrix derivative was reconstituted and applied to the exposed root surface and the bony defect. Flaps were sutured and pressure applied for 5 minutes. The second test defect was treated in a similar manner at least 8 weeks after the first surgery. The patient was given a diary card where any subjective adverse events (erythema, swelling, itching, headache, root hypersensitivity, or pain) were ...Continue Reading

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Citations

Jul 20, 2007·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Luiz Henrique Carvalho BatistaJosealdo Tonholo
Nov 30, 2012·International Journal of Dentistry·Y H Lin, D G Gillam
Aug 7, 2010·The Bulletin of Tokyo Dental College·Atsushi SaitoTakemi Makiishi
Sep 9, 2008·Journal of Clinical Periodontology·Leonardo Trombelli, Roberto Farina
Mar 19, 2016·Journal of Clinical Periodontology·Richard J MironDieter D Bosshardt
Apr 6, 2007·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Anton SculeanMichel Brecx
Oct 13, 2009·The Cochrane Database of Systematic Reviews·Marco EspositoHelen V Worthington
Aug 1, 2011·Clinical Advances in Periodontics·Anton SculeanDieter D Bosshardt

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