Abstract
Several studies reported some success toward regeneration in infrabony defects using enamel matrix derivative (EMD). Clinically and statistically significant improvements in probing depth reduction, clinical attachment levels, and bone fill have been demonstrated. This multi-center study evaluated the potential for sensitization to EMD in a subgroup of periodontal patients treated at least twice with at least 2 months between treatments. Three hundred seventy-six (376) patients in 11 university-based postgraduate periodontics programs and five private practices were selected. Surgeries were performed on infrabony defects. Following reflection of mucoperiosteal flaps and debridement of the root surface and defect, root conditioning (either citric acid pH = 1 or 24% EDTA) was performed and the site was irrigated with sterile saline. Enamel matrix derivative was reconstituted and applied to the exposed root surface and the bony defect. Flaps were sutured and pressure applied for 5 minutes. The second test defect was treated in a similar manner at least 8 weeks after the first surgery. The patient was given a diary card where any subjective adverse events (erythema, swelling, itching, headache, root hypersensitivity, or pain) were ...Continue Reading
References
Oct 1, 1985·Journal of Periodontology·J W CurtisR A Hutchinson
Oct 1, 1994·The Journal of the American Dental Association·S H CroogJ Nalbandian
Nov 1, 1996·Journal of Clinical Periodontology·M B ChabanskiH N Newman
Oct 6, 1997·Journal of Clinical Periodontology·L Hammarström
Oct 6, 1997·Journal of Clinical Periodontology·L Heijl
Oct 6, 1997·Journal of Clinical Periodontology·O ZetterströmS Gestrelius
Oct 6, 1997·Journal of Clinical Periodontology·L HeijlA Ostgren
May 4, 1999·Journal of Periodontology·A SculeanM Brecx
Dec 22, 1999·Journal of Clinical Periodontology·R PontorieroJ Lindhe
Dec 22, 1999·Journal of Clinical Periodontology·G HedenJ Lindhe
Jan 14, 2000·Journal of Periodontal Research·A SculeanT Karring
Jun 29, 2000·Journal of Periodontology·R A Yukna, J T Mellonig
Aug 26, 2000·Journal of Clinical Periodontology·M SilvestriV Cattaneo
Aug 26, 2000·Journal of Periodontology·V LekovicE B Kenney
Sep 6, 2000·Journal of Periodontology·B D BoyanZ Schwartz
Dec 29, 2000·Journal of Periodontology·R H HeardD L Cochran
Jan 13, 2001·Journal of Periodontology·K OkudaH Yoshie
Feb 24, 2001·Journal of Periodontology·S J FroumD Tarnow
May 15, 2001·Journal of Clinical Periodontology·A SculeanE Reich
May 7, 2002·Journal of Periodontology·Anton SculeanMichel Brecx
May 7, 2002·Journal of Periodontology·Péter WindischPeter Eickholz
May 7, 2002·Journal of Periodontology·E Todd ScheyerJames T Mellonig
Citations
Jul 20, 2007·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Luiz Henrique Carvalho BatistaJosealdo Tonholo
Nov 30, 2012·International Journal of Dentistry·Y H Lin, D G Gillam
Sep 3, 2009·Journal of Periodontology·James T MellonigDavid L Cochran
Aug 7, 2010·The Bulletin of Tokyo Dental College·Atsushi SaitoTakemi Makiishi
Sep 9, 2008·Journal of Clinical Periodontology·Leonardo Trombelli, Roberto Farina
Mar 19, 2016·Journal of Clinical Periodontology·Richard J MironDieter D Bosshardt
Apr 6, 2007·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Anton SculeanMichel Brecx
Oct 13, 2009·The Cochrane Database of Systematic Reviews·Marco EspositoHelen V Worthington
Aug 1, 2011·Clinical Advances in Periodontics·Anton SculeanDieter D Bosshardt