A multicenter study for the evaluation of the reference interval for TSH in Italy (ELAS TSH Italian Study)

Clinical Chemistry and Laboratory Medicine : CCLM
Aldo ClericoItalian Section of the European Ligand Assay Society (ELAS)

Abstract

Background The aims of this study were: (1) to calculate reliable thyroid stimulating hormone (TSH) reference intervals using laboratory databases; (2) to evaluate the relationship between TSH, sex and age values in different large Italian populations. Methods The TSH values stored in the laboratory information system of clinical laboratories of four Italian city hospitals, including 146,801 TSH measurements (with the respective age and sex data of individuals) were taken in consideration. Assuming a log-normal distribution, to log-transformed TSH values were applied the Dixon's iterative principle in order to exclude the outliers. At the end of this iterative process 142,821 log-transformed TSH results remained. The four clinical laboratories measured serum TSH concentrations using the same TSH immunoassay method (Access TSH 3rd IS, using UniCel DxI platform). Results The TSH reference interval calculated in the present study (0.362-5.280 mIU/L) is similar to that suggested by the manufacturer for the Access TSH 3rd IS assay (0.45-5.33 mIU/L). TSH values in females were significantly higher than in males (females: mean=2.06 mIU/L; standard deviation [SD]=1.26 mIU/L; n=101,243; males: mean=1.92 mIU/L; SD=1.19 mIU/L; n=41,578; p...Continue Reading

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Citations

Jan 9, 2020·Journal of Clinical Laboratory Analysis·Zhen-Zhen LiYu-Rong Tang
Sep 19, 2019·Scandinavian Journal of Clinical and Laboratory Investigation·Danchen WangLing Qiu
Jan 14, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Andrea PadoanMario Plebani
Aug 9, 2020·Thyroid : Official Journal of the American Thyroid Association·Lei ZhaoWeiping Teng
Jul 28, 2019·Scientific Reports·Daniele SantiManuela Simoni
Nov 30, 2018·Clinical Chemistry and Laboratory Medicine : CCLM·Danchen WangHuaicheng Liu
Feb 5, 2021·Clinical Biochemistry·Paula Argente Del CastilloAntonia Barcelo
Jun 1, 2021·Annals of Clinical Biochemistry·Ruggero Dittadi, Paolo Carraro

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Related Papers

Clinical Chemistry and Laboratory Medicine : CCLM
Aldo ClericoItalian Section of the European Ligand Assay Society (ELAS)
Clinica Chimica Acta; International Journal of Clinical Chemistry
Ruggero DittadiItalian Section of the European Ligand Assay Society (ELAS)
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