A multicenter study of bispectral electroencephalogram analysis for monitoring anesthetic effect

Anesthesia and Analgesia
P S SebelP Manberg


Bispectral analysis (BIS) of the electroencephalogram (EEG) has been shown in retrospective studies to predict whether patients will move in response to skin incision. This prospective multicenter study was designed to evaluate the real-time utility of BIS in predicting movement response to skin incision using a variety of general anesthetic techniques. Three hundred patients from seven study sites received an anesthetic regimen expected to give an approximately 50% movement response at skin incision. EEG was continuously recorded via an Aspect B-500 monitor and BIS was calculated in real time from bilateral frontocentral channels displayed on the monitor. Half of the patients were randomized to a treatment group in which anesthetic drug doses were increased to produce a lower BIS. In the control group, BIS was recorded, but no action taken on the data displayed. A determination of movement in response to skin incision was made in the 2 min succeeding incision. Retrospective pharmacodynamic modeling was performed using STANPUMP to estimate effect-site concentrations of intravenously administered anesthetics. BIS values were significantly higher in the control group (66 +/- 19) versus the BIS-guided group, in which additional an...Continue Reading

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Jan 1, 1991·Anesthesiology·S L Shafer, J R Varvel
Jul 1, 1990·Anesthesiology·C C Hug
Feb 1, 1989·Anesthesia and Analgesia·P F White
Mar 1, 1989·British Journal of Anaesthesia·H SchwildenJ Schüttler
Sep 1, 1985·British Journal of Anaesthesia·P S SebelD A Ingram
Nov 1, 1965·Anesthesiology·E I EgerB Brandstater
Mar 1, 1995·Journal of Clinical Monitoring·P S SebelN Chamoun
Nov 1, 1994·Journal of Clinical Monitoring·J C Sigl, N G Chamoun
Dec 1, 1993·Anesthesiology·J F Antognini, K Schwartz
Sep 1, 1993·Anesthesiology·N MoermanJ Oosting
May 1, 1993·Anesthesiology·A I McEwanP S Glass

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