A multicenter study of levonorgestrel-estradiol contraceptive vaginal rings. II-Subjective and objective measures of effects. An international comparative trial

Irving SivinH A Nash


Comparative clinical trials of 2 sizes of contraceptive vaginal rings and of an oral contraceptive were undertaken at 8 investigational sites (9 clinics). More than 500 women enrolled on each of the 3 study regimens. Side effects of the rings and of Nordette, the oral contraceptive, were evaluated by noting spontaneous complaints, by recording medications taken and by physical examination. Inquiries about changes in the frequency of specific conditions were made at the end of the subjects participation in the first year of the study. The incidence of spontaneous complaints was similar among users of the 2 different-sized rings and of the pill.


Dec 1, 1989·Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception·K SinghS S Ratnam
Feb 24, 2001·Clinical Obstetrics and Gynecology·S A Ballagh
Oct 19, 2013·Pharmaceutical Research·Ignacio M HelblingJulio A Luna
Oct 9, 2012·Contraception·V BracheA Faundes
Oct 12, 2010·Contraception·V Brache, A Faundes
Jul 9, 2004·Fertility and Sterility·Nancy J AlexanderEdio Zampaglione
Oct 6, 2018·Expert Opinion on Pharmacotherapy·Ilza MonteiroLuis Bahamondes
Apr 1, 1993·Annals of Medicine·D R Mishell
Jul 21, 2020·Expert Opinion on Drug Delivery·Peter BoydR Karl Malcolm

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