A multicenter study of nebulized bronchodilator solutions in chronic obstructive pulmonary disease

The American Journal of Medicine
M Friedman

Abstract

A multicenter, 85-day, double-blind, randomized study was conducted to compare the effects of a single-dose and chronic inhalation of ipratropium bromide solution (500 micrograms) to the beta-adrenergic agonist metaproterenol (5% solution, 15 mg) in patients with chronic obstructive pulmonary disease (COPD). Patients were required to have a relatively stable, moderately severe COPD, forced expiratory volume in 1 second (FEV1) < 65% of predicted normal, FEV1 <70% of forced vital capacity (FVC), and a smoking history of > 10 pack-years. Following a 2-week baseline period, patients were randomized into either the ipratropium bromide (106 patients) or metaproterenol (107 patients) study groups. Pulmonary function testing was performed on days 1, 43, and 85. Secondary efficacy variables examined included peak expiratory flow rates, physician's global evaluation, quality of life, COPD symptom score, and use of concomitant medications. FEV1 was comparable between the two groups on day 1 (1.00 and 1.02 liters, ipratropium bromide vs metaproterenol, respectively; p = nonsignificant). The baseline FEV1 increased significantly in the ipratropium bromide group between day 1 and 43 by 10% (from 1.00 to 1.10 liters, p < 0.002) and remained 7...Continue Reading

References

May 1, 1987·Chest·N R Anthonisen, E C Wright
Aug 25, 1988·The New England Journal of Medicine·N J Gross
May 1, 1984·The American Review of Respiratory Disease·N J Gross, M S Skorodin
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Apr 8, 1993·The New England Journal of Medicine·G T Ferguson, R M Cherniack

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Citations

Jul 6, 2010·Respiratory Physiology & Neurobiology·S K RamlalY F Heijdra
Apr 10, 2010·Archivos de bronconeumología·Joaquim GeaLluís Gallart
Apr 21, 2006·The Cochrane Database of Systematic Reviews·S AppletonJ Muhammad

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