A multicentered pharmacokinetic, pharmacodynamic study of once-a-month injectable contraceptives. I. Different doses of HRP112 and of DepoProvera. World Health Organization Task Force on Long-acting Systemic Agents for Fertility Regulation

J Garza-FloresP E Hall


A multicentered study was undertaken at three institutions in Hungary, Mexico and Thailand in women of reproductive age to evaluate the effects of full and half doses of HRP112 (depot-medroxyprogesterone acetate (DMPA) plus estradiol cypionate) and DMPA alone on ovarian function, bleeding patterns and HDL-cholesterol levels. Full dose HRP112 contained 25mg DMPA plus 5mg, of estradiol cypionate and the half dose, 12.5mg DMPA plus 2.5mg of estradiol cypionate. The full and half dose DMPA were 25 and 12.5mg respectively. In all, 88 women were recruited in the study and randomized within each centre, to the four treatment groups. Subjects were studied for a control cycle, three one-month injection intervals and followed-up for a further two months. Serum concentrations of estradiol, progesterone and medroxyprogesterone acetate were determined three times a week during the third injection interval and during the two months of follow-up. While the results from all centres indicated that the four preparations were all effective in inhibiting ovulation for at least one month, there were marked between centre differences in pharmacokinetic profiles. More regular bleeding patterns were observed in women who received the estrogen-progesto...Continue Reading


Jun 1, 1991·Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception·K Singh, S S Ratnam
Dec 1, 1989·Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception·K SinghS S Ratnam
Jan 1, 1991·Journal of Psychosomatic Research·T J Jarvis, M P McCabe
Jan 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·J Garza-FloresG Perez-Palacios
Sep 23, 1998·Contraception·J Garza-FloresG Perez-Palacios
Nov 7, 1998·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·J Garza-Flores
Nov 7, 1998·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·P E Hall
May 15, 2008·Contraception·Markus J SteinerCharles Morrison
Nov 14, 2012·Gynecologic and Obstetric Investigation·Giuseppe BenagianoMario Merialdi
Jan 7, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·David R Friend
Dec 26, 2003·Pharmacotherapy·Alicia B Forinash, Stephanie L Evans
Oct 10, 2008·The Cochrane Database of Systematic Reviews·Maria F GalloCatherine d'Arcangues
Jan 1, 1994·Journal of Obstetrics and Gynaecology·J R NewtonP E Hall

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Clinical Trials
Contraceptive Agents, Female
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