PMID: 8593528Sep 1, 1995Paper

A multicentre assessment of the specificity of ten anti-HBc screening tests

Transfusion Medicine
W HughesJ A Barbara

Abstract

Samples from 1828 donations were screened for anti-HBc at seven sites in the UK using kits supplied by 10 manufacturers. Only 10 (0.55%) donations were considered to have true anti-HBc reactivity and these were detected by all 10 kits. Additional markers of HBV infection were found in nine of these 10 donations. Additional reactives were found by all kits, the number ranging from 1 to 43. In the four more specific kits, the 10 true reactives were clearly distinguished from the 'false reactives' by the strength of the reaction. It is concluded that the reliance on a single ELISA test for anti-HBc diagnosis is unwise. The use of a second test known to be more specific than the screening ELISA is recommended.

References

Jun 22, 1978·The New England Journal of Medicine·J H HoofnagleH J Zimmerman
Jul 1, 1988·Transfusion·P J SchmidtC T Samia

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Citations

Jan 1, 1997·Vox Sanguinis·M H MolijnD J van Rhenen
Jun 27, 1996·The New England Journal of Medicine·G B SchreiberJ J Korelitz
Dec 17, 2004·Journal of Clinical Gastroenterology·Brian CusterKris V Kowdley
Mar 8, 2000·Transplantation·H Smith, P Gibbs
Sep 1, 1996·Transfusion Medicine·G Caspari, W H Gerlich
Dec 14, 2006·Transfusion Medicine·T ZeilerK Radsak
May 18, 2006·American Journal of Preventive Medicine·Sun-Young KimMilton C Weinstein
Sep 15, 2001·Revista Do Instituto De Medicina Tropical De São Paulo·C Almeida NetoD A Chamone
Jan 13, 2001·Journal of Viral Hepatitis·E J Kupek
Oct 19, 2002·Transfusion·Josiane PillonelUNKNOWN Transfusion-Transmissible Agents Working Group of the French Society of Blood Transfusion
Aug 15, 2000·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·R E DomenC M Isada

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