PMID: 8458362Mar 1, 1993Paper

A multicentre, double-blind, placebo-controlled trial of quinapril in mild, chronic heart failure

European Heart Journal
D B NorthridgeH J Dargie

Abstract

Angiotensin converting enzyme (ACE) inhibitors are of proven value in patients with severe chronic heart failure (CHF). Studies of the effects of ACE inhibitors on exercise capacity and quality of life in mild CHF have produced conflicting results. We have studied the effects of quinapril, a new ACE inhibitor with a relatively short plasma half-life, in mild CHF. Once daily (o.d.) dosing was compared with twice daily (b.i.d.) dosing in a three-way cross-over, double-blind, placebo-controlled trial. Thirty-two patients (two female), mean age 59 (range 32-76) years were enrolled in three cardiology centres in the U.K. in 29 patients, and non-ischaemic in three. The mean (range) radionuclide ejection fraction was 20.4% (8%-47%). Following full familiarization with the protocol, the treadmill exercise time (modified Bruce protocol) was determined for each patient during a placebo run-in phase, and at the end of each of three 8-week double-blind treatment phases with quinapril o.d., quinapril b.i.d. (maximal total daily dose 20 mg) and placebo. Three patients were withdrawn due to adverse events while receiving quinapril (unstable angina, exacerbation of CHF and arrhythmia); there were no deaths and no patient was withdrawn due to h...Continue Reading

Citations

Sep 10, 2003·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Antònia AgustíJoan-Ramon Laporte
Apr 28, 2004·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·H GehlenP Stadler

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