A multicentre pharmacoepidemiological study of therapeutic practices in invasive fungal infections in France during 1998-1999

The Journal of Antimicrobial Chemotherapy
Olivier LortholaryRaoul Herbrecht

Abstract

To study the pharmacoepidemiology of the prescription of systemic antifungal agents in 48 French haematology, intensive care and infectious diseases units. Cases of invasive fungal infections (IFI) were identified retrospectively over a 1 year period. Data on underlying condition, IFI diagnosis, antifungal treatment and outcome were collected on the last five cases in each centre. Factors associated with first line therapy and with death were identified by multivariate analysis. Two hundred and nine cases were included (102 aspergillosis, 86 candidiasis, 15 cryptococcosis). Amphotericin B, in different formulations, was the first line therapy in 60%, azoles in 32%, combinations in 8%. Haematological malignancies and neutropenia were associated with less frequent initial prescription of azoles [OR = 0.3 (0.1-0.8) and OR = 0.3 (0.1-0.9), respectively]. In aspergillosis, younger age and neutropenia were associated with less frequent initial prescription of azoles [OR = 0.03 (0.002-0.6) and OR = 0.09 (0.03-0.3), respectively] and previous history of IFI was associated with a higher probability of azole prescription [OR = 17.2 (2.4-124.3)]. In candidiasis, haematological malignancy and co-prescription of nephrotoxic agents were asso...Continue Reading

Citations

Jan 16, 2007·Clinical Microbiology Reviews·M A Pfaller, D J Diekema
Oct 12, 2011·Pharmacology·Friederike TraunmüllerChristian Joukhadar
Jan 25, 2013·BMC Infectious Diseases·John W BaddleyMiriam Tarallo
Sep 13, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·L DrgonaR Barnes
Mar 5, 2016·Mycoses·Sarah A SchmalzleDavid J Riedel
May 21, 2016·Journal of Clinical Pharmacology·Maria Clara Padovani de SouzaAdriano Max Moreira Reis
Oct 7, 2005·Expert Review of Anti-infective Therapy·Livio PaganoLuana Fianchi

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