A multicentre, prospective, randomised, blinded clinical trial to compare some perioperative effects of buprenorphine or butorphanol premedication before equine elective general anaesthesia and surgery

Equine Veterinary Journal
P M TaylorJ C Murrell

Abstract

Buprenorphine, a μ-agonist opioid, has recently been licensed for equine use, but butorphanol, a κ-agonist opioid, is more commonly used in horses. The effect of the 2 opioids has not previously been compared in a large clinical study. To compare post operative analgesia and physiological variables in horses undergoing elective surgery following premedication with either buprenorphine or butorphanol in a conventional clinical setting. Multicentre, prospective, randomised, blinded clinical investigation. Eighty-nine healthy horses admitted for elective surgery to one of 6 UK equine veterinary clinics were premedicated with acepromazine, a nonsteroidal anti-inflammatory drug, and romifidine followed by intravenous (i.v.) buprenorphine or butorphanol. Anaesthesia was induced with diazepam/ketamine and maintained with isoflurane in oxygen. A range of surgical procedures were performed and supplementary anaesthetic agents given as required. Physiological variables were monitored during anaesthesia and pain, ataxia, sedation and vital function were assessed post operatively. Data were analysed using t-tests, ANOVA, Mann-Whitney U-test and Chi-squared test as appropriate and P<0.05 was regarded as significant, except for multiple comp...Continue Reading

References

Jun 1, 1992·Journal of Veterinary Pharmacology and Therapeutics·G C EnglandL Goossens
Sep 1, 1988·Equine Veterinary Journal·K W Clarke, B S Paton
Jan 22, 1994·The Veterinary Record·A P Browning, J A Collins
Oct 5, 2001·The Veterinary Record·J Price, A M Nolan
Jun 18, 2002·The Veterinary Clinics of North America. Equine Practice·Polly M TaylorKhursheed R Mama
Jun 18, 2002·The Veterinary Clinics of North America. Equine Practice·Rachel C Bennett, Eugene P Steffey
Nov 28, 2002·The Veterinary Record·J PriceN K Waran
Sep 23, 2003·Veterinary Anaesthesia and Analgesia·Elizabeth MircicaKaren J Blissitt
Jun 3, 2006·American Journal of Veterinary Research·Pedro BoscanJack R Snyder
Mar 3, 2007·American Journal of Veterinary Research·Adriano B CarregaroAntonio de Queiroz-Neto
Jul 21, 2009·Journal of Veterinary Pharmacology and Therapeutics·A de VriesP M Taylor
Oct 7, 2009·Equine Veterinary Journal·E J LoveJ Murrell
Nov 9, 2010·The Veterinary Clinics of North America. Equine Practice·R Eddie Clutton
Jun 6, 2013·The Veterinary Record·E J LoveJ Murrell
Jun 8, 2013·Veterinary Anaesthesia and Analgesia·Polly TaylorAlan Taylor
Feb 17, 2015·The Onderstepoort Journal of Veterinary Research·Lundi NtantisoAbdalla A Latif

❮ Previous
Next ❯

Citations

Sep 23, 2018·Journal of Veterinary Pharmacology and Therapeutics·Tamara L GrubbJennifer L Davis
Mar 16, 2018·Experimental and Therapeutic Medicine·Li FengMing Lin
Apr 10, 2021·Equine Veterinary Journal·Catriona Mackenzie

❮ Previous
Next ❯

Methods Mentioned

BETA
sedation

Related Concepts

Related Feeds

Ataxias (MDS)

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Ataxia

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Ataxias

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on different types of ataxias here.