A multicentre, randomised, double blind, placebo controlled phase II study of subcutaneous interferon beta-1a in the treatment of patients with active rheumatoid arthritis

Annals of the Rheumatic Diseases
Judith van HoltenP P Tak

Abstract

To assess the efficacy of interferon beta (IFN beta) in combination with methotrexate in treatment of patients with rheumatoid arthritis. 209 patients with active rheumatoid arthritis, who had been on methotrexate for at least six months and at a stable dose for four weeks before study entry, were randomised in double blind fashion to receive placebo (0.05 ml or 0.5 ml), IFN beta 2.2 microg (0.05 ml), or IFN beta 44 microg (0.5 ml), given subcutaneously three times weekly for 24 weeks. The primary efficacy measure was a change in radiological scores at week 24. The secondary endpoint was the proportion of patients who met the ACR 20% improvement criteria at the end of the study. Synovial biopsy specimens were obtained before and after treatment from a subset of patients. Immunohistochemistry was used to detect the presence of inflammatory cells and the results were measured by digital image analysis. Collagen crosslinks were measured in urine at different times throughout the study. Analysis of radiological scores and clinical variable showed no changes in any of the groups, and there were no differences between the groups. On microscopic analysis of synovial tissue there was no significant change in the scores for infiltration...Continue Reading

References

Oct 1, 1994·Arthritis and Rheumatism·M E WeinblattE Gall
Dec 31, 1998·Arthritis and Rheumatism·B BresnihanP Musikic
Mar 13, 1999·Annals of Internal Medicine·L W MorelandM E Weinblatt
Jun 23, 1999·Rheumatology·P P TakF C Breedveld
Apr 19, 2002·Nature·Hiroshi TakayanagiTadatsugu Taniguchi
Apr 16, 2003·Annals of the Rheumatic Diseases·J VencovskýS Růzicková

❮ Previous
Next ❯

Citations

Jun 9, 2005·Best Practice & Research. Clinical Rheumatology·Danielle Gerlag, Paul P Tak
Feb 20, 2013·Nature Reviews. Rheumatology·William H RobinsonJeremy Sokolove
Dec 5, 2006·Current Opinion in Rheumatology·Frances A Y Borg, David A Isenberg
Jun 25, 2005·Annals of the Rheumatic Diseases·M D SmithUNKNOWN OMERACT synovial special interests group
Nov 5, 2008·The Journal of Clinical Investigation·Lawrence Steinman
Jul 1, 2005·Arthritis Research & Therapy·Michel P M VierboomBert 't Hart
Feb 24, 2009·Arthritis Research & Therapy·Vibeke Strand, Jeremy Sokolove
Jun 6, 2009·Arthritis Research & Therapy·Erik af KlintStaffan Lindblad
Jan 14, 2010·Arthritis Research & Therapy·Gerd R BurmesterUNKNOWN Kitasato Meeting Faculty*
Apr 16, 2010·Arthritis Research & Therapy·George D Kalliolias, Lionel B Ivashkiv
Feb 15, 2011·Arthritis Research & Therapy·Mary K Crow
Nov 11, 2010·Arthritis Research & Therapy·Tineke CantaertLisa G M van Baarsen
Mar 28, 2012·Biomarkers in Medicine·George D Kalliolias, Kyriakos A Kirou
Mar 1, 2008·Expert Opinion on Drug Discovery·Michel VierboomBert A 't Hart
Mar 1, 2008·Expert Opinion on Drug Discovery·Marcus D Köller
Jan 6, 2006·Scandinavian Journal of Rheumatology·L StruebyR M Taylor-Gjevre
Feb 2, 2013·Translational Research : the Journal of Laboratory and Clinical Medicine·Christopher H EvansPaul D Robbins
Nov 17, 2012·Biochemical Pharmacology·Malte BachmannHeiko Mühl
Dec 15, 2015·Nature Reviews. Rheumatology·Iain B McInnesJohn D Isaacs
Oct 6, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Maida WongRam Raj Singh
Mar 31, 2007·Drug Discovery Today·Michel P M VierboomBert A 't Hart
Mar 1, 2007·Arthritis and Rheumatism·Susan E SweeneyGary S Firestein
Apr 21, 2016·BMC Musculoskeletal Disorders·Maria FilkovaJames Galloway
May 12, 2009·Biochemical Pharmacology·Anson K AbrahamDonald E Mager
Aug 20, 2016·BMC Musculoskeletal Disorders·Jeroen P JansenGene V Wallenstein
Jul 14, 2017·Nature Reviews. Rheumatology·Carl OrrSander W Tas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.