A multicentre, randomised, open-label, controlled trial evaluating equivalence of inhalational and intravenous anaesthesia during elective craniotomy

European Journal of Anaesthesiology
Giuseppe CiterioNeuroMorfeo Study Group

Abstract

A clear preference for intravenous or inhalational anaesthesia has not been established for craniotomy in patients without signs of cerebral hypertension. The NeuroMorfeo trial was designed to test equivalence of inhalational and intravenous anaesthesia maintenance techniques in the postoperative recovery of patients undergoing elective supratentorial surgery. This trial is a multicentre, randomised, open-label, equivalence design. A balanced stratified randomisation scheme was maintained using a centralised randomisation service. Equivalence was tested using the two one-sided tests procedure. Fourteen Italian neuroanaesthesia centres participated in the study from December 2007 to March 2009. Adults, 18 to 75 years old, scheduled for elective supratentorial intracranial surgery under general anaesthesia were eligible for enrolment if they had a normal preoperative level of consciousness and no clinical signs of intracranial hypertension. Patients were randomised to one of three anaesthesia maintenance protocols to determine if sevoflurane-remifentanil or sevoflurane-fentanyl were equivalent to propofol-remifentanil. The primary outcome was the time to achieve an Aldrete postanaesthesia score of at least 9 after tracheal extuba...Continue Reading

Associated Clinical Trials

References

Feb 1, 1981·British Journal of Anaesthesia·C Traynor, G M Hall
Feb 1, 1995·Journal of Clinical Anesthesia·J A Aldrete
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Citations

Feb 1, 2014·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Jason ChuiLashmi Venkatraghavan
Oct 27, 2015·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Alana M FlexmanAdrian W Gelb
Oct 18, 2015·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Katherine B HaganJuan P Cata
Mar 24, 2016·BMC Anesthesiology·Jasmina Markovic-BozicVesna Novak-Jankovic
Sep 22, 2015·Frontiers in Surgery·Geoffrey P Dobson
Apr 23, 2015·BMJ Open·Li-Mei YanUNKNOWN Acute Brain Injury and Critical Care Research Collaboration (ABC Research Collaboration)
Apr 29, 2016·British Journal of Anaesthesia·J LiL Meng
Mar 17, 2017·Frontiers in Medicine·Tumul ChowdhuryBernhard Schaller
Sep 10, 2016·The Cochrane Database of Systematic Reviews·Hemanshu PrabhakarVidhu Anand
Sep 3, 2013·Current Opinion in Anaesthesiology·Federico BilottaGiovanni Rosa
Oct 2, 2014·Journal of Neurosurgical Anesthesiology·Stanlies D'Souza
Nov 21, 2019·The Cochrane Database of Systematic Reviews·Imelda M GalvinIan Gilron
May 25, 2013·European Journal of Anaesthesiology·Shreyas Bhavsar, Anh Q Dang
Aug 3, 2013·European Journal of Anaesthesiology·Giuseppe Citerio, UNKNOWN NeuroMorfeo Study Group
Feb 23, 2013·European Journal of Anaesthesiology·Giuseppe Citerio, UNKNOWN NeuroMorfeo Study Group
Dec 18, 2012·European Journal of Anaesthesiology·Francisco A LoboGavin N C Kenny
May 31, 2019·Current Opinion in Anaesthesiology·Alana M FlexmanLingzhong Meng
Nov 15, 2013·European Journal of Anaesthesiology·Franklin Dexter
Jan 1, 2015·International Anesthesiology Clinics·Abirami KumaresanRuma Bose
Jul 13, 2012·European Journal of Anaesthesiology·Michael Nathanson, Malachy Columb
Mar 27, 2020·Korean journal of anesthesiology·Seok-Jin Lee, Tae-Yun Sung
May 26, 2021·Best Practice & Research. Clinical Anaesthesiology·Rafael BadenesFederico Bilotta

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