A multicentre validation study of the diagnostic value of plasma neurofilament light.

Nature Communications
Nicholas J AshtonOskar Hansson

Abstract

Increased cerebrospinal fluid neurofilament light (NfL) is a recognized biomarker for neurodegeneration that can also be assessed in blood. Here, we investigate plasma NfL as a marker of neurodegeneration in 13 neurodegenerative disorders, Down syndrome, depression and cognitively unimpaired controls from two multicenter cohorts: King's College London (n = 805) and the Swedish BioFINDER study (n = 1,464). Plasma NfL was significantly increased in all cortical neurodegenerative disorders, amyotrophic lateral sclerosis and atypical parkinsonian disorders. We demonstrate that plasma NfL is clinically useful in identifying atypical parkinsonian disorders in patients with parkinsonism, dementia in individuals with Down syndrome, dementia among psychiatric disorders, and frontotemporal dementia in patients with cognitive impairment. Data-driven cut-offs highlighted the fundamental importance of age-related clinical cut-offs for disorders with a younger age of onset. Finally, plasma NfL performs best when applied to indicate no underlying neurodegeneration, with low false positives, in all age-related cut-offs.

References

Jun 10, 2000·Cerebral Cortex·S M ResnickA B Zonderman
Mar 29, 2006·Neurology·J BrettschneiderH Tumani
Sep 13, 2006·Archives of Neurology·Henrik ZetterbergAnders Wallin
Oct 2, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·H ZetterbergP M Andersen
Jan 8, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Luigi Ferrucci
Aug 20, 2009·Current Alzheimer Research·Ronald C Petersen
Nov 13, 2009·Annals of the New York Academy of Sciences·Simon LovestoneUNKNOWN AddNeuroMed Consortium
Dec 2, 2011·Neurology·G D RabinoviciW J Jagust
May 14, 2014·Journal of Alzheimer's Disease : JAD·Daniel AlcoleaAlberto Lleó
Jul 16, 2014·Journal of Alzheimer's Disease : JAD·Daniela GalimbertiElio Scarpini
Oct 30, 2015·Neurology·Shorena JanelidzeOskar Hansson
Dec 27, 2016·Wellcome Open Research·Carla M StartinAndré Strydom
Feb 10, 2017·Neurology·Oskar HanssonUNKNOWN Swedish BioFINDER study
Mar 28, 2017·JAMA Neurology·Niklas MattssonUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Jul 13, 2017·The New England Journal of Medicine·Robert H Brown, Ammar Al-Chalabi
Feb 9, 2018·Nature·Akinori NakamuraKatsuhiko Yanagisawa
Apr 11, 2018·Alzheimer's Research & Therapy·Andre StrydomUNKNOWN LonDownS Consortium
Apr 15, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Clifford R JackUNKNOWN Contributors
Jul 28, 2018·Journal of Internal Medicine·K Blennow, H Zetterberg
Sep 2, 2018·Nature Reviews. Neurology·Michael KhalilJens Kuhle
Oct 10, 2018·Nature Reviews. Neurology·Harald HampelKaj Blennow
Oct 16, 2018·International Psychogeriatrics·Latha VelayudhanTraolach Brugha
Jan 9, 2019·Frontiers in Aging Neuroscience·Sarah WestwoodSimon Lovestone
Jan 22, 2019·Nature Medicine·Oliver PreischeUNKNOWN Dominantly Inherited Alzheimer Network
Mar 1, 2019·Neurology·Tainá M MarquesMarcel M Verbeek
May 18, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Andrea PilottoAlessandro Padovani

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Citations

Jun 5, 2021·Nature Medicine·Oskar Hansson
Jun 22, 2021·Journal of Alzheimer's Disease : JAD·Andrea PilottoAlessandro Padovani
Aug 28, 2021·Journal of Clinical Medicine·Laia Montoliu-GayaNicholas James Ashton
Jul 17, 2021·Neurology·Michel J GrotheUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Oct 6, 2021·Journal of Neurology·Joseph Pleen, Ryan Townley
Dec 4, 2021·EMBO Molecular Medicine·Antoine LeuzyOskar Hansson

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