A Multicentric Prospective Incidence Study of Guillain-Barré Syndrome in Italy. The ITANG Study

Neuroepidemiology
Maria Donata BenedettiITANG study group

Abstract

To assess Guillain-Barré syndrome (GBS) incidence we relied on the Italian Network for the study of GBS (ITANG) established in 2010 in 7 Italian regions to analyse the association between influenza vaccination and GBS. All individuals aged ≥18 years, presenting with clinical manifestations that suggested GBS according to the universally accepted Asbury's diagnostic criteria (1990) were prospectively notified to a centralised database by ITANG neurologists over the period October 1, 2010-September 30, 2011. Through a telephone survey, 9 trained interviewers followed up the cases to diagnosis and then for 1 year since hospital discharge. Validation of case reporting was performed with the support of administrative data in 5 regions. We found 365 cases fulfilling the definition for GBS or one of its variants over 19,846,068 population ≥18 years of age, yielding an annual incidence rate of 1.84 per 100,000 (95% CI 1.65-2.03), 2.30 (95% CI 1.99-2.60) in men and 1.41 (95% CI 1.18-1.64) in women. A highly significant peak of incidence was observed in February 2011 as compared to reference month (September 2011, rate ratio 3.3:1, p < 0.01). In Italy, GBS incidence was among the highest reported in Europe and higher than previously obse...Continue Reading

Citations

Apr 19, 2017·Health Security·Shu-Wan JianDing-Ping Liu
Dec 20, 2016·Journal of the Peripheral Nervous System : JPNS·Alexandra DelannoyAlain Weill
Nov 3, 2017·Journal of the Peripheral Nervous System : JPNS·Jussi O T SipiläVille Kytö
Nov 14, 2018·Journal of the Peripheral Nervous System : JPNS·Luana BenedettiGiovanni L Mancardi
Jan 9, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Enrico GranieriIlaria Casetta
Oct 6, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Valeria PradaLuana Benedetti
Aug 31, 2020·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Fernanda Tavares-Da-SilvaJens-Ulrich Stegmann
Jun 20, 2018·Frontiers in Immunology·Kristy PurnamawatiChester Lee Drum
May 5, 2021·Journal of the Peripheral Nervous System : JPNS·Mercedes ChiesaCristina Vázquez
Aug 18, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Mozaffar HosseininezhadZahra Gholipour Soleimani

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