A multicontrast approach for comprehensive imaging of substantia nigra

NeuroImage
Jason LangleyXiaoping Hu

Abstract

We characterize the contrast behavior of substantia nigra (SN) in both magnetization transfer (MT) imaging, which is believed to be sensitive to neuromelanin (NM), and susceptibility weighted imaging (SWI). Images were acquired with a MT prepared dual echo gradient echo sequence. The first echo was taken as the MT contrast image and the second was used to generate the SWI image. SN volumes were segmented from these two types of images using a thresholding method. The spatial and signal characteristics of the extracted SWI and MT volumes were compared. Both images showed the presence of SN but the volumes of the SN identified in the two are spatially incongruent. The MT volume was more caudal than the SWI volume and with only a 12% overlap between the two volumes. Considering the SN volumes in each hemisphere separately, the average distances between the centers of mass of the volumes from the two types images are 5.1±1.1mm and 4.1±1.2mm, respectively. The frequency offsets (homodyne filtered phase/echo time) for the volumes derived from MT (NM) images and SWI images are 0.09±0.32radians/s and -1.12±0.57radians/s (p<0.0001), respectively. The MT contrasts for the two volumes are 0.16±0.02 and 0.10±0.03 (p<0.001), respectively. O...Continue Reading

References

Nov 1, 1992·Annals of Neurology·D C GermanD M Mann
Oct 1, 1991·Brain : a Journal of Neurology·J M Fearnley, A J Lees
Aug 1, 1997·Radiology·W S EnochsR Weissleder
Apr 26, 2001·NMR in Biomedicine·R M HenkelmanS J Graham
Aug 23, 2001·Medical Image Analysis·M Jenkinson, S Smith
Jan 20, 2004·Journal of Chemical Neuroanatomy·Suzanne N Haber
Jun 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Luigi ZeccaFabio A Zucca
Aug 31, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·E Mark HaackeJürgen R Reichenbach
Oct 27, 2004·NeuroImage·Stephen M SmithPaul M Matthews
Jun 26, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jeff H DuynMasaki Fukunaga
Jul 27, 2007·Journal of Magnetic Resonance Imaging : JMRI·E Mark HaackeWolff Kirsch
Dec 7, 2007·Journal of Magnetic Resonance Imaging : JMRI·Patrice PéranUmberto Sabatini
Sep 10, 2008·Biochimica Et Biophysica Acta·Amanda M Snyder, James R Connor
Dec 27, 2008·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Toshiki NakaneShinji Naganawa
Jul 4, 2009·Magnetic Resonance Imaging·Jason Langley, Qun Zhao
Mar 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jongho LeeJeff H Duyn
May 11, 2010·Parkinsonism & Related Disorders·Mustafa Efkan Colpan, Konstantin V Slavin
Jun 1, 2010·Journal of Magnetic Resonance Imaging : JMRI·Karla HoppHelen Nichol
Aug 26, 2010·Brain : a Journal of Neurology·Patrice PéranUmberto Sabatini
Aug 16, 2011·Internal Medicine·Kenichi KashiharaFumiyo Higaki
May 3, 2012·NeuroImage·Marc Guitart-MasipRaymond J Dolan
May 16, 2013·Parkinsonism & Related Disorders·Masako MukaiShiro Matsubara
Oct 12, 2013·NeuroImage·Issel Anne L LimPeter C M van Zijl

❮ Previous
Next ❯

Citations

Mar 31, 2016·Human Brain Mapping·Jason LangleyXiaoping Hu
Sep 7, 2016·Frontiers in Aging Neuroscience·Ioannis U IsaiasAntonella Costa
Dec 17, 2016·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A Martin-BastidaP Piccini
Dec 23, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Jason LangleyXiaoping P Hu
Dec 27, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Paula TrujilloAntonella Costa
Feb 28, 2017·Human Brain Mapping·Daniel E HuddlestonXiaoping P Hu
Sep 7, 2016·Scientific Reports·Jae-Hyeok LeeHyungJoon Cho
Jan 1, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Jason LangleyXiaoping Hu
May 9, 2019·The British Journal of Radiology·Eung Yeop KimJongho Lee
Feb 27, 2018·Current Opinion in Neurology
Aug 29, 2020·Brain : a Journal of Neurology·Emma BiondettiStéphane Lehéricy
Jul 22, 2019·Brain : a Journal of Neurology·Matthew J BettsDorothea Hämmerer
Oct 11, 2020·Journal of Magnetic Resonance Imaging : JMRI·Marieke van der PluijmElsmarieke van de Giessen
Oct 23, 2020·Brain Structure & Function·Nikos PriovoulosDimo Ivanov
Dec 15, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Sonoko OshimaYuji Nakamoto
Sep 27, 2020·Parkinsonism & Related Disorders·Jason LangleyXiaoping Hu
Jun 25, 2019·NeuroImage·Paula TrujilloDaniel O Claassen
Apr 4, 2021·Tomography : a Journal for Imaging Research·Tzu-Wei LeeHua-Shan Liu
May 19, 2021·European Journal of Radiology·Liesbeth RenemanElsmarieke van de Giessen
Jul 10, 2021·NPJ Parkinson's Disease·Frédérique DepierreuxGaëtan Garraux

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Atypical Parkinsonism (MDS)

Atypical Parkinsonism presents with the same signs and symptoms of Parkinson's disease, but do not respond to typical Parkionson's disease treatment with levodopa. Atypical Parkinsonism is thought to be associated with abnormal protein buildup within brain cells. Here is the latest on Atypical Parkinsonism.

Related Papers

Zeitschrift für medizinische Physik
E Mark Haacke
Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine
Toshiki NakaneShinji Naganawa
Journal of Magnetic Resonance Imaging : JMRI
Günther GrabnerMarkus Barth
© 2022 Meta ULC. All rights reserved