A multidimensional antimicrobial stewardship intervention targeting aztreonam use in patients with a reported penicillin allergy

International Journal of Clinical Pharmacy
Sara M SwearingenAnthony J Guarascio

Abstract

Local antimicrobial susceptibility patterns should be considered for antimicrobial therapy decisions. Antibiogram data can guide beta-lactam antibiotic use in the presence of a penicillin allergy, particularly when allergic cross-reactivity among antibiotic agents is unlikely. To evaluate the effect of a multidimensional antimicrobial stewardship intervention to improve antibiogram-driven antibiotic selection for patients with a reported penicillin allergy receiving aztreonam. This historically controlled, quasi-experimental study compared historical aztreonam use with prospective antibiotic selection following a pharmacist-led intervention in patients with a penicillin allergy. The impact of this intervention on aztreonam use, antimicrobial selection, patient allergy profile updates, length of stay, in-hospital mortality, and antibiotic cost savings was assessed. A significant reduction in median days of aztreonam therapy (4.0 vs. 2.0; p = 0.0001) and median days of therapy per 1000 patient days (14.5 vs. 9.3; p = 0.0001) was found in the intervention group. A pharmacist-led antimicrobial stewardship intervention facilitated antibiogram-driven antibiotic therapy while reducing aztreonam use in patients without an anaphylactic ...Continue Reading

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Citations

May 19, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jason A TrubianoElizabeth J Phillips
Aug 25, 2018·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Anthony PhanCalvin Tucker
Feb 23, 2018·Journal of Pharmacy Practice·Kacie E ClarkAmeen Pirasteh
Jun 30, 2019·Pharmacy : Journal of Pharmacy, Education and Practice·Elizabeth W CovingtonC Whitney White
Mar 16, 2018·International Journal of Clinical Pharmacy·Geoffrey C WallHayden L Smith
Jul 7, 2018·Open Forum Infectious Diseases·Justin R ChenDavid A Khan
Mar 28, 2019·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Kimberly G BlumenthalErica S Shenoy
Nov 13, 2019·American Journal of Therapeutics·Ryan SteinerLucia Rose
May 10, 2017·The Journal of Allergy and Clinical Immunology. in Practice·Kimberly G BlumenthalPaige G Wickner
Dec 11, 2021·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Courtney L GaberinoSheran S Mahatme

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