A multidimensional cohort study of late toxicity after intensity modulated radiotherapy for sinonasal cancer.

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Maja Bendtsen SharmaCai Grau

Abstract

To evaluate the occurrence of late toxicity after curatively intended intensity modulated radiotherapy (IMRT) for sinonasal cancer and assess dose-response associations. Patients treated with IMRT in 2008-2016 were included. Cross sectional examinations of toxicity from the optic pathway, the brain, the pituitary gland and the nose were performed along with quality of life - (QoL) and dose-response analyses. Twenty-seven patients were enrolled; median age was 67 years (range 47-83). Five patients (19%) had radiation-related ocular toxicity. The risk of visual acuity impairment increased with increasing dose (grade 2 odds ration (OR) 1.12, p = 0.01; grade 3 OR 1.14, p = 0.02) and dose constraint violations (grade 2, OR = 21, p < 0.01; grade 3, OR = 41, p < 0.01). Six patients (22%) exhibited evidence of radiation-related hypopituitarism, but no dose-response association was detected. Seventeen patients (63%) had impaired olfactory function. The risk of olfactory impairment increased with higher stage (OR = 3.32, p = 0.03). Three patients (11%) had structural abnormalities in irradiated areas of the brain, and impaired cognitive function was present in 17 patients (63%). Cognitive, physical, role functioning as well as fatigue an...Continue Reading

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Citations

Jan 26, 2021·Clinical and Translational Radiation Oncology·M B SharmaC Grau
Jun 28, 2021·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·T LeleuJ Thariat

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