A multidimensional comparison of morphine and hydromorphone patient-controlled analgesia

Anesthesia and Analgesia
S E RappJ M Ching

Abstract

Although patient-controlled analgesia (PCA) pumps have been in use for more than a decade, the optimal PCA analgesic has yet to be identified. Many drugs are used; however, morphine remains the "gold standard" of opioid analgesics worldwide. The present study evaluated morphine and hydromorphone (Dilaudid) PCA with respect to analgesic efficacy, side effects, mood, and cognitive function. Sixty-one opioid naive patients undergoing lower abdominal surgery participated in the double-blind protocol. Verbal rating scores, use of medication, and side effects for the two medications were recorded. Cognitive functioning was assessed by computation of Digit Symbol and Trails Making B Tests. Self-reported affective state (mood) was measured by Profile of Mood States (POMS) inventory. Both medications provided adequate analgesia without a difference in side effects. Cognitive performance was poorer in the hydromorphone group (P < 0.05). Patients receiving hydromorphone reported less anger/hostility (P < 0.01) and generally better mood elevations on the other subscales than those receiving morphine. A similar incidence of side effects and dose medication can be anticipated with morphine and hydromorphone. When considering cognitive effect...Continue Reading

References

Jun 1, 1973·Anesthesiology·A H Goldberg
Dec 1, 1964·Journal of Abnormal Psychology·D M MCNAIR, M LORR

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Citations

May 24, 2005·Journal of Pain and Symptom Management·Alison Murray, Neil A Hagen
Feb 19, 2003·Journal of Pain and Symptom Management·Columba Quigley, Phil Wiffen
Mar 1, 2002·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M ZhengM C Ong
Aug 24, 2010·Pain Management Nursing : Official Journal of the American Society of Pain Management Nurses·Ann M Schreier
Nov 6, 2008·Clinics in Geriatric Medicine·Anita S BagriJorge G Ruiz
Jan 14, 2010·Thoracic Surgery Clinics·Anita S BagriJorge G Ruiz
Nov 7, 2006·Journal of the American College of Surgeons·Michael J Demeure, Mindy J Fain
Mar 15, 2002·Anesthesiology Clinics of North America·Sabine Kost-Byerly
Mar 15, 2005·Anesthesiology Clinics of North America·Pamela E Macintyre
Feb 1, 2011·Current Therapeutic Research, Clinical and Experimental·Sang Hyun LeeWoo Seog Sim
Jul 20, 2001·British Journal of Anaesthesia·P E Macintyre
Nov 11, 2017·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Jacob L HutchinsPamela P Palmer
Aug 3, 2002·The British Journal of Surgery·G J Rubin, M Hotopf
Jul 24, 2020·Paediatric Anaesthesia·Rajiv BalyanVidya Chidambaran
Mar 15, 2006·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Debra K WeinerSusan Lieber

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