A multifunctional β-cyclodextrin-conjugate photodelivering nitric oxide with fluorescence reporting

International Journal of Pharmaceutics
Gábor BenkovicsSalvatore Sortino

Abstract

This contribution reports the design, synthesis and photochemical properties of a novel cationic, water soluble, β-cyclodextrin (βCD) conjugate integrating an anthracene moiety and a nitroaniline derivative within the primary side of the βCD scaffold. Photoinduced energy transfer between the anthracene and the nitroaniline chromophores effectively suppresses the fluorescence of the anthracene unit. Excitation with visible light triggers the release of nitric oxide (NO) from the nitroaniline chromophore, accompanied to the concomitant revival of the anthracene fluorescence, which acts as an optical reporter for detecting the amount of the NO released. Furthermore, the anthracene moiety photogenerates singlet oxygen (1O2) sequentially to NO release. The conjugate is also able to accommodate hydrophobic guests within the βCD cavity, as proven by using naphthalene as a model compound. In view of the key role NO and 1O2 play as anticancer and antibacterial species, the present βCD derivative represents an intriguing candidate for further studies in biopharmaceutical research addressed to multimodal therapeutic applications.

Citations

Aug 25, 2018·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Aurore Fraix, Salvatore Sortino
Oct 14, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Krishna Kalyani BeharaN D Pradeep Singh
Jun 19, 2021·Chemistry : a European Journal·Aurore FraixSalvatore Sortino
Oct 30, 2021·ACS Applied Materials & Interfaces·Yun QianElizabeth J Brisbois

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