A multifunctional plasmonic chip for bacteria capture, imaging, detection, and in situ elimination for wound therapy

Nanoscale
Xia GaoYaqing Liu

Abstract

A multifunctional plasmonic gold chip has been constructed for early diagnosis and highly effective killing of bacteria, which is critical for human health. The chip features high bacterial capture efficiency, plasmon-enhanced fluorescence (PEF) and surface-enhanced Raman scattering (SERS) and can act as a highly sensitive sensor for dual-mode bacteria imaging and detection (down to 102 CFU mL-1) with good reliability and accuracy. The developed assay can distinguish Gram-positive S. aureus bacteria from Gram-negative E. coli bacteria, providing valuable information for therapy. Importantly, the chip presents excellent photothermal antibacterial activity (98%) and can inactivate both Gram-positive and Gram-negative bacteria in situ. Furthermore, the chip was used to effectively promote the wound healing process in bacteria infected mice in vivo, showing great potential for antibacterial applications.

References

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Jul 19, 2019·ACS Applied Materials & Interfaces·Ling ZhangZisheng Tang

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Citations

Sep 24, 2020·Analytical Methods : Advancing Methods and Applications·Xiangru BaiJiming Hu
Dec 12, 2020·Advanced Science·Xia ZhouPinghua Sun
Nov 14, 2020·Advanced Healthcare Materials·Guijian GuanMing-Yong Han
Sep 11, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiaojia LiuXing Ma

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Methods Mentioned

BETA
chip
chips
AFM
Fluorescence
biosensors
scanning
X-ray
atomic force microscopy

Software Mentioned

COMSOL Multiphysics
Image J

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