A multilocus genotypic analysis of Cryptosporidium meleagridis

The Journal of Eukaryotic Microbiology
S GlabermanLihua Xiao

Abstract

Cryptosporidium meleagridis is a common cause of cryptosporidiosis in birds. In addition, recent reports have described the parasite as an etiologic agent of cryptosporidiosis in both immunocompetent and immunocompromised humans. Therefore, it is important to genetically characterize isolates of C. meleagridis from different hosts and geographic areas, and to develop molecular tools to differentiate isolates from various hosts or areas. In this study, a total of 11 isolates of Cryptosporidium meleagridis from both human and avian hosts were examined at three genetic loci: the small-subunit rRNA, 60-kDa glycoprotein precursor, and 70-kDa heat shock protein genes. Two genotypes of C. meleagridis were seen at the small-subunit rRNA locus. These differed from each other by the presence or lack of a heterogeneous copy of the gene and an ATT repeat. The 60-kDa glycoprotein precursor gene divided these eleven isolates of C. meleagridis into six genotypes with high sequence diversity between groups. The highest genetic heterogeneity, however, was seen at the 70-kDa heat shock protein locus, and was primarily present at the 3' end of the gene. This heterogeneity separated eight isolates of C. meleagridis into six genotypes. These data c...Continue Reading

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Citations

Mar 27, 2010·Parasitology Research·Niichiro Abe, Ikuko Makino
Jan 17, 2004·Clinical Microbiology Reviews·Lihua XiaoSteve J Upton
Sep 30, 2010·Clinical and Vaccine Immunology : CVI·Jeffrey W PriestJudith L Isaac-Renton
Jan 24, 2006·Clinical and Vaccine Immunology : CVI·Jeffrey W PriestPatrick J Lammie
Mar 30, 2010·The American Journal of Tropical Medicine and Hygiene·Síle F MolloyCelia V Holland
Aug 10, 2010·Experimental Parasitology·Yaoyu FengLihua Xiao
Aug 8, 2009·Veterinary Parasitology·Judit Plutzer, Panagiotis Karanis
Mar 24, 2009·Experimental Parasitology·Ronald Fayer
Nov 26, 2008·Experimental Parasitology·Michelle L PowerSally Williamson
Apr 15, 2014·International Journal for Parasitology·Yuanfei WangLihua Xiao
Oct 2, 2012·International Journal for Parasitology·Charlotte SilverlåsMarianne Lebbad
Jan 22, 2008·FEMS Immunology and Medical Microbiology·Lihua Xiao, Yaoyu Feng
Oct 9, 2015·Infection Ecology & Epidemiology·Jessica BeserMarianne Lebbad
Apr 18, 2014·Journal of Clinical Microbiology·Christen Rune StensvoldMarianne Lebbad
Mar 20, 2019·Frontiers in Cellular and Infection Microbiology·Żaneta KopaczMarta Kicia
Jun 27, 2019·Revista Do Instituto De Medicina Tropical De São Paulo·Flavia Souza CunhaJosé Mauro Peralta

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