A multimodal approach for determining brain networks by jointly modeling functional and structural connectivity

Frontiers in Computational Neuroscience
Wenqiong XueAndrew R Mayer

Abstract

Recent innovations in neuroimaging technology have provided opportunities for researchers to investigate connectivity in the human brain by examining the anatomical circuitry as well as functional relationships between brain regions. Existing statistical approaches for connectivity generally examine resting-state or task-related functional connectivity (FC) between brain regions or separately examine structural linkages. As a means to determine brain networks, we present a unified Bayesian framework for analyzing FC utilizing the knowledge of associated structural connections, which extends an approach by Patel et al. (2006a) that considers only functional data. We introduce an FC measure that rests upon assessments of functional coherence between regional brain activity identified from functional magnetic resonance imaging (fMRI) data. Our structural connectivity (SC) information is drawn from diffusion tensor imaging (DTI) data, which is used to quantify probabilities of SC between brain regions. We formulate a prior distribution for FC that depends upon the probability of SC between brain regions, with this dependence adhering to structural-functional links revealed by our fMRI and DTI data. We further characterize the funct...Continue Reading

References

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Citations

Jun 18, 2015·Frontiers in Computational Neuroscience·Qawi K TelesfordEric D Kolaczyk
Jul 7, 2017·Human Brain Mapping·Francesco de PasqualePatrice Peran
Aug 16, 2017·IEEE Transactions on Bio-medical Engineering·Shilpa DangPrasun K Roy
Sep 17, 2017·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Erin D Bigler
Apr 15, 2021·Scientific Reports·S WeinE W Lang
Jun 18, 2021·Computational Intelligence and Neuroscience·Simon WeinElmar W Lang

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Software Mentioned

Matlab
FMRIB ( Functional Magnetic Resonance Imaging of the Brain ) S...
Linux

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