A multimodal approach to capture post-stroke temporal dynamics of recovery.

Journal of Neural Engineering
Camilla PierellaSilvestro Micera

Abstract

Several training programs have been developed in the past to restore motor functions after stroke. Their efficacy strongly relies on the possibility to assess individual levels of impairment and recovery rate. However, commonly used clinical scales rely mainly on subjective functional assessments and are not able to provide a complete description of patients' neuro-biomechanical status. Therefore, current clinical tests should be integrated with specific physiological measurements, i.e. kinematic, muscular, and brain activities, to obtain a deep understanding of patients' condition and of its evolution through time and rehabilitative intervention. We proposed a multivariate approach for motor control assessment that simultaneously measures kinematic, muscle and brain activity and combines the main physiological variables extracted from these signals using principal component analysis (PCA). We tested it in a group of six sub-acute stroke subjects evaluated extensively before and after a four-week training, using an upper-limb exoskeleton while performing a reaching task, along with brain and muscle measurements. After training, all subjects exhibited clinical improvements correlating with changes in kinematics, muscle synergies...Continue Reading

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References

Feb 1, 1989·Brain : a Journal of Neurology·D BourbonnaisW Z Rymer
Aug 2, 1994·Proceedings of the National Academy of Sciences of the United States of America·F A Mussa-IvaldiE Bizzi
Oct 6, 2000·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·H J HermensG Rau
Feb 4, 2003·Nature Neuroscience·Andrea d'AvellaEmilio Bizzi
Apr 12, 2003·Archives of Physical Medicine and Rehabilitation·Susan E FasoliNeville Hogan
Jun 24, 2003·Experimental Brain Research·M C CirsteaM F Levin
Jan 16, 2004·The Journal of Physiology·Y P IvanenkoF Lacquaniti
Oct 9, 2004·Stroke; a Journal of Cerebral Circulation·Gert KwakkelPeter Langhorne
Mar 4, 2005·Medical & Biological Engineering & Computing·R RienerG Colombo
Mar 24, 2006·Journal of Neurophysiology·G CappelliniF Lacquaniti
May 16, 2008·Annals of Neurology·Steven C Cramer
Jul 25, 2009·American Journal of Respiratory and Critical Care Medicine·Carlo Sorrentino, Emma Di Carlo
Nov 3, 2009·Proceedings of the National Academy of Sciences of the United States of America·Vincent C K CheungEmilio Bizzi
Mar 2, 2010·NeuroImage·Juliane BritzChristoph M Michel
Apr 20, 2010·The New England Journal of Medicine·Albert C LoPeter Peduzzi
Sep 11, 2010·Neurorehabilitation and Neural Repair·Margit Alt MurphyKatharina S Sunnerhagen
Oct 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Dimitri Van de VilleChristoph M Michel
Jun 24, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Pavel MusienkoGrégoire Courtine
Dec 20, 2011·IEEE Transactions on Bio-medical Engineering·S BalasubramanianE Burdet
Mar 1, 2012·Neurorehabilitation and Neural Repair·Alessandro PanareseSilvestro Micera
Aug 4, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Simon Finnigan, Michel J A M van Putten
Aug 22, 2012·Proceedings of the National Academy of Sciences of the United States of America·Vincent C K CheungEmilio Bizzi
May 4, 2013·Frontiers in Computational Neuroscience·Emilio Bizzi, Vincent C K Cheung
Oct 8, 2013·Journal of Neuroengineering and Rehabilitation·Peppino TropeaSilvestro Micera
Dec 18, 2013·Stroke; a Journal of Cerebral Circulation·Hermano I KrebsBruce T Volpe
Mar 19, 2014·Archives of Physical Medicine and Rehabilitation·Ilse LamersPeter Feys
May 30, 2014·Brain : a Journal of Neurology·Emmanuel Carrera, Giulio Tononi
Sep 14, 2014·Journal of Neuroengineering and Rehabilitation·Nurdiana NordinBurkhard Wünsche
Jan 21, 2015·International Journal of Rehabilitation Research. Internationale Zeitschrift Für Rehabilitationsforschung. Revue Internationale De Recherches De Réadaptation·Kyoung Bo LeeByong Yong Hwang
Apr 17, 2015·BMC Neurology·Margit Alt MurphyIlse Lamers
Apr 19, 2015·Progress in Brain Research·Carolee J Winstein, Dorsa Beroukhim Kay
May 1, 2015·Journal of Neuroengineering and Rehabilitation·Martina CosciaSilvestro Micera
Jul 25, 2015·Journal of Hand Therapy : Official Journal of the American Society of Hand Therapists·Anne Martine BertrandKarin Diserens
Jan 24, 2016·Journal of Neuroengineering and Rehabilitation·Elvira PirondiniSilvestro Micera
Jul 13, 2016·Proceedings of the National Academy of Sciences of the United States of America·Joshua Sarfaty SiegelMaurizio Corbetta
Jul 26, 2016·Frontiers in Computational Neuroscience·Siddharth S SivakumarRoberto F Galán
Sep 10, 2016·Journal of Neuroengineering and Rehabilitation·Alessandro PanareseSilvestro Micera
Feb 24, 2017·Nature Neuroscience·Choong-Wan WooTor D Wager
May 27, 2017·Brain Topography·Filippo ZappasodiFranca Tecchio
Oct 19, 2017·Scientific Reports·Elvira PirondiniSilvestro Micera
Apr 6, 2018·The International Journal of Neuroscience·Ophélie PilaÉmilie Hutin
Apr 12, 2018·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Paulina KielibaFiorenzo Artoni
Apr 17, 2018·Physiotherapy Theory and Practice·Gyrd ThraneMargit Alt Murphy

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Citations

Feb 3, 2021·Journal of Neural Engineering·Nerea Irastorza-LandaAnder Ramos-Murguialday
Jul 22, 2021·Methods and Protocols·Roberto Di Marco On Behalf Of The Pro Gait Consortium

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