Abstract
Alzheimer's disease (AD) and vascular cognitive impairment and dementia (VCID) are major causes of dementia, and when combined lead to accelerated cognitive loss. We hypothesized that biomarkers of neurodegeneration and neuroinflammation could be used to stratify patients into diagnostic groups. Diagnosis of AD can be made biologically with detection of amyloid and tau proteins in the cerebrospinal fluid (CSF) and vascular disease can be identified with diffusion tensor imaging (DTI). We recruited patients with cognitive complaints and made an initial clinical diagnosis. After one year of follow-up we made a biological diagnosis based on the use of biomarkers obtained from DTI, CSF AD, and inflammatory proteins, and neuropsychological testing. Patients with AD had primarily findings of neurodegeneration (CSF showing increased tau and reduced amyloid), while patients with neuroinflammation had abnormal DTI mean diffusion (MD) in the white matter. Using the biological biomarkers resulted in many of the clinically diagnosed AD patients moving into mixed dementia (MX). Biomarkers of inflammation tended to be higher in the MX than in either the AD or VCID, suggesting dual pathology leads to increased inflammation, which could explai...Continue Reading
References
Aug 1, 1979·Neurology·G A RosenbergJ M Bicknell
Jan 1, 1987·Archives of Neurology·V C HachinskiH Merskey
Jul 1, 1984·Neurology·G McKhannE M Stadlan
Apr 1, 1995·Neurology·L R Caplan
Aug 19, 2006·Stroke; a Journal of Cerebral Circulation·Vladimir HachinskiGabrielle G Leblanc
Jun 15, 2007·Neurology·Julie A SchneiderDavid A Bennett
Sep 20, 2007·Brain : a Journal of Neurology·Gabriel GoldEnikö Kövari
Jan 24, 2009·Lancet Neurology·Gary A Rosenberg
Apr 26, 2011·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Guy M McKhannCreighton H Phelps
Jul 9, 2011·Nature Medicine·Costantino Iadecola, Josef Anrather
Aug 10, 2011·Archives of Neurology·Joshua A SonnenThomas J Montine
Aug 24, 2011·Journal of Alzheimer's Disease : JAD·Maria BjerkeUlf Andreasson
Nov 6, 2012·Lancet Neurology·Pauline MaillardCharles DeCarli
Jul 12, 2013·Brain : a Journal of Neurology·Jon B ToledoJohn Q Trojanowski
Dec 24, 2013·Neuron·Clifford R Jack, David M Holtzman
Sep 10, 2014·Expert Review of Neurotherapeutics·Branko N Huisa, Gary A Rosenberg
Dec 17, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Heather M SnyderMaria C Carrillo
Jan 27, 2015·Journal of Neurology, Neurosurgery, and Psychiatry·Gary A RosenbergRonald Schrader
Feb 28, 2015·Alzheimer's Research & Therapy·Helena C Chui, Liliana Ramirez-Gomez
Jul 23, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Gary A RosenbergVladimir Hachinski
Mar 20, 2016·Cellular and Molecular Neurobiology·Gary A Rosenberg
Nov 7, 2017·Neuropharmacology·Rajikha RajaArvind Caprihan
Feb 7, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Marco DueringMartin Dichgans
Apr 15, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Clifford R JackUNKNOWN Contributors