A Multimodal Eye Assessment in Psoriatic Arthritis Patients sine -Psoriasis: Evidence for a Potential Association with Systemic Inflammation

Journal of Clinical Medicine
Maria Sole ChimentiRoberto Perricone

Abstract

Ocular involvement in Psoriatic Arthritis (PsA) patients is mainly associated with uveitis but there remains a paucity of data on dry eye and retinal abnormalities. We aimed to analyze dry eye and subclinical retinal abnormalities in a cohort of PsA patients sine-psoriasis (PsO). PsA patients sine-PsO were enrolled. Best-corrected-visual-acuity, ocular-surface-disease-index (OSDI), Schirmer test, tear film breakup-time, standard-automated-perimetry (SAP, mean deviation-MD, pattern standard deviation-PSD), fundus-perimetry (FP), and spectral-domain-optical-coherence-tomography (SD-OCT) were performed. A total of 80 eyes from 40 PsA patients with moderate-severe disease activity, and 70 eyes from 35 healthy control (HC) were evaluated. Higher dry eye prevalence occurred in PsA than HC (p < 0.0001). ESR was positively related with OSDI (p < 0.001) and negatively related with Schirmer (p = 0.007). In PsA, SAP registered higher MD (p < 0.0001) and higher PSD (p = 0.005) in comparison with HC. PSD resulted positively correlated with ESR (p = 0.04) and CRP (p = 0.01), while MD showed a negative correlation with CRP (p = 0.01). Both FP mean differential sensitivity and mean defect were lower in PsA then HC (p < 0.0001). In PsA, FP diff...Continue Reading

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Citations

Sep 10, 2020·Biologics : Targets & Therapy·Maria Sole ChimentiRoberto Perricone
Aug 5, 2021·Experimental and Therapeutic Medicine·Maria-Magdalena ConstantinFlorentina Furtunescu

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Methods Mentioned

BETA
ESR

Software Mentioned

SAP
TruTrack
GraphPad
Spectralis
Standard
SITA
OCT
MP1
GraphPad Prism

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