PMID: 9008270Jan 1, 1997Paper

A multiple-dose pharmacokinetic interaction study between didanosine (Videx) and ciprofloxacin (Cipro) in male subjects seropositive for HIV but asymptomatic

Biopharmaceutics & Drug Disposition
C A Knupp, R H Barbhaiya

Abstract

The pharmacokinetics of didanosine and ciprofloxacin were evaluated following the administration of multiple oral doses of each drug as a single agent or in combination. Didanosine was dosed as the Videx chewable/dispersible tablet, which contains the antacids dihydroxyaluminum sodium carbonate and magnesium hydroxide. Sixteen HIV-seropositive male subjects were randomly assigned to two groups of eight each. Group A received didanosine (200 mg q 12h) for 3d, followed by didanosine (200 mg q 12h) and ciprofloxacin (750 mg q 12h) for 3d, and finished with another course of didanosine (200 mg q 12h for 3 d). Group B began with ciprofloxacin, followed by the combination, and finished with ciprofloxacin using the same doses and schedule as utilized in group A. During the combination phase of the study, ciprofloxacin was administered 2 h prior to didanosine. Serial blood and urine samples were collected on study days 4, 8, and 12 for the quantitative determination of didanosine and ciprofloxacin using validated HPLC methods. The plasma and urine data were subjected to noncompartmental pharmacokinetic analysis. A statistically significant decrease in the average AUC and UR values of ciprofloxacin was noted when it was given with didan...Continue Reading

Citations

Feb 27, 2003·Clinical Pharmacokinetics·Monique M R de MaatJos H Beijnen
Mar 13, 2002·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·W W Yew
Jan 17, 2008·Respirology : Official Journal of the Asian Pacific Society of Respirology·Wing Wai Yew, Chi Chiu Leung
Mar 24, 2015·Tuberculosis·S TheeH S Schaaf
Aug 30, 2007·The Journal of Infectious Diseases·Charles D WellsKarin Weyer
Oct 20, 2001·Pharmacotherapy·D N Fish

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