PMID: 8613685Mar 1, 1996Paper

A multiple-radical model for radiation action on DNA and the dependence of OER on LET

International Journal of Radiation Biology
B D Michael, K M Prise

Abstract

We have developed a multiple-radical model of the chemical modification reactions involving oxygen and thiols relevant to the interactions of ionizing radiations with DNA. The treatment is based on the Alper and Howard-Flanders equation but considers the case where more than one radical may be involved in the production of lesions in DNA. This model makes several predictions regarding the induction of double strand breaks in DNA by ionizing radiation and the role of sensitizers such as oxygen and protectors such as thiols which act at the chemical phase of radiation action via the involvement of free radicals. The model predicts a decreasing OER with increasing LET on the basis that as radical multiplicity increases so will the probability that, even under hypoxia, damage will be fixed and lead to lesion production. The model can be considered to provide an alternative hypothesis to those of "interacting radicals' or of "oxygen-in-the-track'.

References

Aug 1, 1979·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·B C MillarJ J Steele
Nov 1, 1988·International Journal of Radiation Biology·D Blöcher
Sep 1, 1974·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·T Alper, P E Bryant
Apr 1, 1995·International Journal of Radiation Biology·K M PriseB D Michael
Jan 1, 1994·International Journal of Radiation Biology·K M Prise

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Citations

Apr 1, 2014·Radiation Oncology·Cody D SchlaffKevin A Camphausen
Nov 26, 2015·Scientific Reports·Walter TinganelliEmanuele Scifoni
Nov 18, 2000·Journal of Theoretical Biology·J Barilla, M Lokajícek
Sep 17, 2008·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Ivano TavernelliMarie-Françoise Politis
May 6, 2003·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·K H ChadwickM J P Brugmans
May 5, 2011·Physics in Medicine and Biology·Tatiana Wenzl, Jan J Wilkens
Mar 10, 2009·Radiation Research·Jintana Meesungnoen, Jean-Paul Jay-Gerin
Aug 26, 2017·Physics in Medicine and Biology·O SokolM Krämer
Jan 16, 2020·International Journal of Molecular Sciences·Daria BoscoloEmanuele Scifoni
Dec 28, 2019·International Journal of Molecular Sciences·Juliette ThariatFrançois Chevalier
Aug 25, 2021·Medical Physics·Anna A FriedlVincent Favaudon

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