PMID: 3753772Jan 10, 1986Paper

A multiple sequence alignment program

Nucleic Acids Research
E Sobel, H M Martinez

Abstract

A program is described for simultaneously aligning two or more molecular sequences which is based on first finding common segments above a specified length and then piecing these together to maximize an alignment scoring function. Optimal as well as near-optimal alignments are found, and there is also provided a means for randomizing the given sequences for testing the statistical significance of an alignment. Alignments may be made in the original alphabets of the sequences or in user-specified alternate ones to take advantage of chemical similarities (such as hydrophobic-hydrophilic).

References

Jan 1, 1985·Bulletin of Mathematical Biology·D Davison
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M MurataJ L Sussman
Jul 11, 1983·Nucleic Acids Research·H M Martinez

❮ Previous
Next ❯

Citations

Jan 1, 1992·Virus Genes·M S Oberste, M A Gonda
Dec 1, 1988·Journal of Molecular Evolution·W R Taylor
May 1, 1997·Bulletin of Mathematical Biology·J I Naus, K N Sheng
Jul 1, 1992·Bulletin of Mathematical Biology·S C ChanD K Chiu
Mar 1, 1993·Bulletin of Mathematical Biology·A K WongD K Chiu
Jan 1, 1990·Bulletin of Mathematical Biology·O Gotoh
Aug 1, 1990·Computers and Biomedical Research, an International Journal·D E Foulser, N G Core
Feb 1, 1992·Molecular and Biochemical Parasitology·C Werner, T V Rajan
Jun 1, 1992·Biochimie·S BrouilletP P Slonimski
Jan 1, 1993·Bio Systems·L I BrodskyS I Feranchuk
Apr 1, 1990·Genetic Analysis, Techniques and Applications·A M Barber, J V Maizel
Aug 27, 1999·Advances in Biophysics·O Gotoh
Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D J LipmanJ D Kececioglu
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S R Holbrook, S H Kim
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R KaplanJ Schlessinger
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J D StubbsG Parry
Jan 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·K SaukkonenE I Tuomanen
Aug 1, 1990·The Journal of Cell Biology·M J IgnatiusL F Reichardt
May 1, 1991·The Journal of Cell Biology·E W NapolitanoL F Reichardt
Sep 1, 1990·The Journal of Experimental Medicine·P Tekamp-OlsonA Cerami
Dec 1, 1991·The Journal of Experimental Medicine·Y LiD N Posnett
Sep 1, 1993·The Journal of Experimental Medicine·E RozdzinskiE Tuomanen
Jul 1, 1996·AIDS Research and Human Retroviruses·W W RothV C Bond
Jan 1, 1994·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Z ZhangW Miller
Nov 25, 1986·Nucleic Acids Research·M S Waterman
Mar 11, 1988·Nucleic Acids Research·H M Martinez
Jun 26, 1989·Nucleic Acids Research·H MargalitJ V Maizel
Sep 25, 1989·Nucleic Acids Research·C Miles, M Meuth
Dec 25, 1991·Nucleic Acids Research·P B HackettR B Petersen
Oct 1, 1991·European Journal of Biochemistry·F A Shotkoski, A M Fallon
May 11, 2007·Annual Review of Genomics and Human Genetics·Mathieu Blanchette
Jan 26, 2006·BMC Bioinformatics·Hao-Teng ChangMargaret Dah-Tsyr Chang
Jan 1, 1991·Proteins·G D SchulerD J Lipman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved