A multiscale approach to curvature modulated sorting in biological membranes

Journal of Theoretical Biology
M MerckerW Jäger

Abstract

Combining different theoretical approaches, curvature modulated sorting in lipid bilayers fixed on non-planar surfaces is investigated. First, we present a continuous model of lateral membrane dynamics, described by a nonlinear PDE of fourth order. We then prove the existence and uniqueness of solutions of the presented model and simulate membrane dynamics using a finite element approach. Adopting a truly multiscale approach, we use dissipative particle dynamics (DPD) to parameterize the continuous model, i.e. to derive a corresponding macroscopic model. Our model predicts that curvature modulated sorting can occur if lipids or proteins differ in at least one of their macroscopic elastic moduli. Gradients in the spontaneous curvature, the bending rigidity or the Gaussian rigidity create characteristic (metastable) curvature dependent patterns. The structure and dynamics of these membrane patterns are investigated qualitatively and quantitatively using simulations. These show that the decomposition time decreases and the stability of patterns increases with enlarging moduli differences or curvature gradients. Presented phase diagrams allow to estimate if and how stable curvature modulated sorting will occur for a given geometry ...Continue Reading

References

Feb 18, 1972·Science·S J Singer, G L Nicolson
May 9, 1988·Physical Review Letters·I SzleiferW M Gelbart
Mar 1, 1993·Physical Review Letters·U Seifert
Jun 3, 1996·Physical Review Letters·T Taniguchi
Oct 6, 2000·Physical Review Letters·S RamaswamyJ Prost
Oct 25, 2000·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·Y JiangA Saxena
Apr 24, 2002·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·C M Chen
May 3, 2003·Nature Reviews. Molecular Cell Biology·Juan S Bonifacino, Jennifer Lippincott-Schwartz
Dec 17, 2004·Physical Review Letters·Mohamed Laradji, P B Sunil Kumar
Mar 4, 2005·The Journal of Chemical Physics·Grace Brannigan, Frank L H Brown
Apr 20, 2005·The Journal of Chemical Physics·Ask F Jakobsen
May 17, 2005·Biophysical Journal·T BaumgartJ T Jenkins
Jun 7, 2005·Current Biology : CB·Anthony G Lee
Oct 26, 2005·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Marieke KranenburgBerend Smit
Dec 27, 2005·The Journal of Chemical Physics·Mohamed Laradji, P B Sunil Kumar
Mar 28, 2006·Nature Materials·Tae-Young YoonSin-Doo Lee
May 17, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Raghuveer ParthasarathyJay T Groves
May 23, 2006·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Bojan BozicSasa Svetina
Jun 30, 2006·Biophysical Journal·Ira R Cooke, Markus Deserno
Sep 8, 2006·The European Physical Journal. E, Soft Matter·J-M Allain, M Ben Amar
Sep 27, 2006·The Journal of Chemical Physics·G IllyaJ C Shillcock
May 16, 2007·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Tomoyoshi Yoshigaki
Mar 21, 2008·Physical Review Letters·Stefan SemrauCornelis Storm
Mar 21, 2008·Physical Review Letters·Bartosz RózyckiReinhard Lipowsky
Mar 29, 2008·European Biophysics Journal : EBJ·Jeremy PencerJohn Katsaras
Sep 23, 2008·Biophysical Journal·David P Siegel
Oct 15, 2008·Physical Review Letters·Ulrich SchmidtMatthias Weiss
Mar 13, 2009·Physical Chemistry Chemical Physics : PCCP·H Jelger Risselada, Siewert J Marrink
Apr 8, 2009·Biophysical Journal·A Tian, T Baumgart
Apr 28, 2009·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·John S LowengrubAxel Voigt
May 20, 2009·The Journal of Physical Chemistry. B·Qing Liang, Yu-Qiang Ma
Aug 12, 2009·Journal of Biological Physics·Yajun Yin, Cunjing Lv
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Marzuk M KamalJonathon Howard
Apr 7, 2010·Proceedings of the National Academy of Sciences of the United States of America·Michael HeinrichTobias Baumgart
Sep 6, 2011·The Journal of Physical Chemistry. B·Moritz MerckerDirk Hartmann

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Citations

Feb 19, 2015·Biophysical Journal·Moritz Mercker, Anna Marciniak-Czochra
Mar 19, 2014·Advances in Colloid and Interface Science·Patricia BassereauAurore Lévy
Jan 30, 2019·International Journal for Numerical Methods in Biomedical Engineering·Vladimir YushutinMaxim Olshanskii
Apr 12, 2014·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Ricard V SoléJosep Sardanyés
Nov 9, 2021·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Frits VeermanAnna Marciniak-Czochra

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