A Multisite Randomized Controlled Trial of Mindfulness-Based Stress Reduction in the Treatment of Posttraumatic Stress Disorder.

Psychiatric Research and Clinical Practice
Lori L DavisJ Douglas Bremner

Abstract

Posttraumatic stress disorder (PTSD) is often difficult to treat, and many patients do not achieve full remission. Complementary and integrative health approaches, such as mindfulness meditation, are intended to be integrated with evidence-based treatment. This study examined the efficacy of mindfulness-based stress reduction (MBSR) in the treatment of PTSD in U.S. military veterans. Veterans with a diagnosis of PTSD (N=214) were randomly assigned to either 90-minute group MBSR or present-centered group therapy (PCGT) for eight weeks. Follow-up assessments were obtained at baseline and weeks 3, 6, 9 (primary endpoint), and 16. Both the MBSR and PCGT groups achieved significant improvement in PTSD as measured by the Clinician-Administered PTSD Scale for DSM-IV (CAPS-IV), with no statistically significant differences between groups. However, compared with PCGT, the MBSR group showed a statistically significant improvement in PTSD on the self-reported PTSD Checklist for DSM-IV over the nine weeks. This difference was not maintained posttreatment, at week 16. Strengths of the study include its large sample size, multisite design, active control group, single-blind outcome ratings, fidelity monitoring, large minority representation,...Continue Reading

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Citations

Sep 17, 2020·International Journal of Environmental Research and Public Health·Óliver JiménezJosé M García-Montes
Nov 20, 2019·The Cochrane Database of Systematic Reviews·Bradley E BelsherPaula P Schnurr
Mar 15, 2020·Cognitive, Affective & Behavioral Neuroscience·Maria M QuinonesKathi Heffner
Jun 9, 2021·Chinese Journal of Traumatology = Zhonghua Chuang Shang Za Zhi·Lu-Na SunWei-Zhi Liu

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