Abstract
Humans die at an increasing rate until late in life, when mortality rates level off. The causes of the late-life mortality plateau have been debated extensively over the past few years. Here, I examine mortality patterns separately for each of the leading causes of death. The different causes of death show distinct mortality patterns, providing some clues about the varying acceleration of mortality at different ages. I examine mortality patterns by first plotting the data of mortality rate versus age on a log-log scale. The slope of the age-specific mortality rate at each age is the age-specific acceleration of mortality. About one-half of total deaths have causes with similar shapes for the age-specific acceleration of mortality: a steady rise in acceleration from midlife until a well-defined peak at 80 years, followed by a nearly linear decline in acceleration. This first group of causes includes heart disease, cerebrovascular disease, and accidental deaths. A second group, accounting for about one-third of all deaths, follows a different pattern of age-specific acceleration. These diseases show an approximately linear rise in acceleration to a peak at 35-45 years of age, followed by a steep and steady decline in acceleration...Continue Reading
References
Jan 1, 1997·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·S Horiuchi, J R Wilmoth
Jan 1, 1997·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·S Horiuchi
Jul 1, 1997·Current Biology : CB·B Charlesworth, L Partridge
May 23, 1998·Science·J W VaupelJ W Curtsinger
Dec 16, 1998·Demography·S Horiuchi, J R Wilmoth
Jun 22, 2000·Environmental and Molecular Mutagenesis·M G AndreassiA Clerico
Jul 14, 2000·Genetical Research·S D Pletcher, J W Curtsinger
Dec 29, 2000·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M R Rose, L D Mueller
Dec 18, 2001·Journal of Theoretical Biology·L A Gavrilov, N S Gavrilova
Nov 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·E Georg Luebeck, Suresh H Moolgavkar
Feb 6, 2004·Current Biology : CB·Steven A Frank
Aug 21, 2004·International Journal of Epidemiology·Steven A Frank
Nov 4, 2004·International Journal of Epidemiology·Richard Doll
Citations
Apr 23, 2011·Biogerontology·Bruce A Carnes
Dec 8, 2009·Anti-cancer Drugs·Piyun ChaoPatrick J Sinko
Nov 16, 2013·Biochemistry. Biokhimii︠a︡·A G Malygin
Dec 24, 2005·BMC Cancer·Steven A FrankSteven M Lipkin
May 11, 2013·Ontogenez·A G Malygin
Feb 23, 2012·Scientific Reports·Byung Mook Weon, Jung Ho Je
Jan 17, 2017·Ecology Letters·Michael E Hochberg, Robert J Noble
Oct 28, 2016·F1000Research·Steven A Frank
Apr 25, 2019·Behavioral Sciences·Steven A Frank
Oct 26, 2021·Aging·Richard B RichardsonDennis S Deng