A multistage theory of age-specific acceleration in human mortality

BMC Biology
Steven A Frank

Abstract

Humans die at an increasing rate until late in life, when mortality rates level off. The causes of the late-life mortality plateau have been debated extensively over the past few years. Here, I examine mortality patterns separately for each of the leading causes of death. The different causes of death show distinct mortality patterns, providing some clues about the varying acceleration of mortality at different ages. I examine mortality patterns by first plotting the data of mortality rate versus age on a log-log scale. The slope of the age-specific mortality rate at each age is the age-specific acceleration of mortality. About one-half of total deaths have causes with similar shapes for the age-specific acceleration of mortality: a steady rise in acceleration from midlife until a well-defined peak at 80 years, followed by a nearly linear decline in acceleration. This first group of causes includes heart disease, cerebrovascular disease, and accidental deaths. A second group, accounting for about one-third of all deaths, follows a different pattern of age-specific acceleration. These diseases show an approximately linear rise in acceleration to a peak at 35-45 years of age, followed by a steep and steady decline in acceleration...Continue Reading

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Citations

Apr 23, 2011·Biogerontology·Bruce A Carnes
Nov 16, 2013·Biochemistry. Biokhimii︠a︡·A G Malygin
Dec 24, 2005·BMC Cancer·Steven A FrankSteven M Lipkin
Feb 23, 2012·Scientific Reports·Byung Mook Weon, Jung Ho Je
Jan 17, 2017·Ecology Letters·Michael E Hochberg, Robert J Noble
Oct 28, 2016·F1000Research·Steven A Frank

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