A multivariate analysis of clinical and morphological prognostic factors in squamous cell carcinoma of the vulva

Gynecologic and Obstetric Investigation
B Smyczek-GargyaJ Dietl

Abstract

Clinical and histological data of 168 patients with squamous cell carcinoma of the vulva were analyzed with respect to survival. 151 patients underwent surgery, 12 patients were treated with primary radiation and in 5 patients no treatment was performed. Follow-up lasted from at least 2 up to 22 years' posttreatment. In univariate analysis, the following factors were highly significant: presurgery lymph node status, tumor infiltration beyond the vulva, tumor grading, histological inguinal lymph node status, pre- and postsurgery tumor stage, depth of invasion and tumor diameter. In the multivariate analysis (Cox regression), the most powerful factors were shown to be histological inguinal lymph node status, tumor diameter and tumor grading. The multivariate logistic regression analysis worked out as main prognostic factors for metastases of inguinal lymph nodes: presurgery inguinal lymph node status, tumor size, depth of invasion and tumor grading. Based on these results, tumor biology seems to be the decisive factor concerning recurrence and survival. Therefore, we suggest a more conservative treatment of vulvar carcinoma. Patients with confined carcinoma to the vulva, with a tumor diameter up to 3 cm and without clinical suspe...Continue Reading

Citations

Sep 13, 2011·Archives of Gynecology and Obstetrics·C DittmerM Thill
Sep 6, 2003·International Journal of Radiation Oncology, Biology, Physics·Angela KatzCharles F Levenback
Jun 29, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·M H M OonkA G J van der Zee
Oct 22, 2011·Critical Reviews in Oncology/hematology·Angiolo GadducciAndrea Riccardo Genazzani
Feb 10, 2006·Gynecologic Oncology·Francesco RaspagliesiShigeki Kusamura
Jun 28, 2014·The Cochrane Database of Systematic Reviews·Theresa A LawrieAngela Ralte
Jun 27, 2019·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·G GarganeseA C Testa

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