A Multivariate Assessment of Age-Related Cognitive Impairment in Octodon degus.

Frontiers in Integrative Neuroscience
Daniela S RiveraNibaldo C Inestrosa

Abstract

Aging is a progressive functional decline characterized by a gradual deterioration in physiological function and behavior. The most important age-related change in cognitive function is decline in cognitive performance (i.e., the processing or transformation of information to make decisions that includes speed of processing, working memory, and learning). The purpose of this study is to outline the changes in age-related cognitive performance (i.e., short-term recognition memory and long-term learning and memory) in long-lived Octodon degus. The strong similarity between degus and humans in social, metabolic, biochemical, and cognitive aspects makes it a unique animal model for exploring the mechanisms underlying the behavioral and cognitive deficits related to natural aging. In this study, we examined young adult female degus (12- and 24-months-old) and aged female degus (38-, 56-, and 75-months-old) that were exposed to a battery of cognitive-behavioral tests. Multivariate analyses of data from the Social Interaction test or Novel Object/Local Recognition (to measure short-term recognition memory), and the Barnes maze test (to measure long-term learning and memory) revealed a consistent pattern. Young animals formed a separat...Continue Reading

References

Feb 1, 1979·Journal of Comparative and Physiological Psychology·C A Barnes
Mar 1, 1989·Current Eye Research·M B Datiles, H Fukui
Jan 1, 1989·Neurobiology of Aging·A L MarkowskaD S Olton
Mar 1, 1980·Canadian Journal of Psychology·C A BarnesW K Honig
Jan 1, 1997·Annual Review of Psychology·M Gallagher, P R Rapp
Jan 1, 1997·Experimental Gerontology·S N Austad
Nov 11, 1999·Current Biology : CB·A R McIntoshP J Bennett
Feb 19, 2000·The American Journal of Clinical Nutrition·J SelhubI H Rosenberg
Oct 21, 2000·Learning & Memory·M C Alvarado, J Bachevalier
Sep 26, 2002·Canadian Journal of Experimental Psychology = Revue Canadienne De Psychologie Expérimentale·Cheryl L Grady
Nov 5, 2002·NeuroImage·Roberto CabezaAnthony R McIntosh
Jan 25, 2003·Experimental Gerontology·C A Erickson, C A Barnes
Feb 1, 2003·Neurobiology of Learning and Memory·E Ronald de KloetMelly S Oitzl
Feb 1, 1962·Journal of Comparative and Physiological Psychology·B A CAMPBELL, E H CAMPBELL
Jan 13, 2004·Physiological Reviews·M A Lynch
Jan 31, 2004·ILAR Journal·Theresa M Lee
Jul 13, 2004·Annals of the New York Academy of Sciences·Donna J Holmes
Dec 8, 2004·Neurobiology of Aging·Nikolaos PitsikasEugenio E Muller
Dec 9, 2004·Psychology and Aging·Brent J SmallLars Bäckman
Mar 8, 2005·Neurobiology of Aging·Nibaldo C InestrosaFrancisco Aboitiz
Jun 7, 2005·Experimental Gerontology·Maria Noêmia M de LimaNadja Schröder
Jul 19, 2005·Annual Review of Neuroscience·Guo-li Ming, Hongjun Song
Feb 1, 2006·Journal of Neuroscience Research·O von Bohlen und HalbachK Unsicker
Aug 29, 2006·Trends in Cognitive Sciences·John P Aggleton, Malcolm W Brown
Oct 20, 2006·Physiology & Behavior·Takeshi MuraiHisashi Ohta
Mar 21, 2007·Neuroscience and Biobehavioral Reviews·Ekrem DereMaria A De Souza Silva
Aug 4, 2007·Physiology & Behavior·Julie A Markham, Janice M Juraska
Apr 9, 2008·Progress in Brain Research·Nelson Cowan
Aug 2, 2008·Journal of the Neurological Sciences·Samantha GalluzziGiovanni B Frisoni
Nov 28, 2008·Annual Review of Psychology·Denise C Park, Patricia Reuter-Lorenz
Jan 24, 2009·Behavioural Brain Research·Natalija PopovićMiroljub Popović
Feb 13, 2009·Developmental Psychology·Carolyn Rovee-Collier, Kimberly Cuevas
Apr 4, 2009·The Veterinary Clinics of North America. Exotic Animal Practice·Mark S Edwards
Jun 3, 2009·Behavioral Neuroscience·Graham L BarrettChristine Tsafoulis
Jun 9, 2009·International Review of Neurobiology·Maria T CasertaJun Tan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.