A Murine Intestinal Intraepithelial NKp46-Negative Innate Lymphoid Cell Population Characterized by Group 1 Properties

Cell Reports
Aline Van AckerGeorges Leclercq

Abstract

The Ly49E receptor is preferentially expressed on murine innate-like lymphocytes, such as epidermal Vγ3 T cells, intestinal intraepithelial CD8αα+T lymphocytes, and CD49a+liver natural killer (NK) cells. As the latter have recently been shown to be distinct from conventional NK cells and have innate lymphoid cell type 1 (ILC1) properties, we investigated Ly49E expression on intestinal ILC populations. Here, we show that Ly49E expression is very low on known ILC populations, but it can be used to define a previously unrecognized intraepithelial innate lymphoid population. This Ly49E-positive population is negative for NKp46 and CD8αα, expresses CD49a and CD103, and requires T-bet expression and IL-15 signaling for differentiation and/or survival. Transcriptome analysis reveals a group 1 ILC gene profile, different from NK cells, iCD8α cells, and intraepithelial ILC1. Importantly, NKp46-CD8αα-Ly49E+cells produce interferon (IFN)-γ, suggesting that this previously unrecognized population may contribute to Th1-mediated immunity.

Citations

Nov 30, 2019·Immunology·Stephanie C Ganal-Vonarburg, Claudia U Duerr
Feb 11, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Hongjian ZhouChao Ke
Feb 28, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ali NazmiDanyvid Olivares-Villagómez
Mar 21, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Luc Van Kaer, Danyvid Olivares-Villagómez
May 3, 2018·Nature Reviews. Immunology·Benjamin D McDonaldAlbert Bendelac

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