PMID: 9177864Jun 1, 1997Paper

A murine model of human myeloma bone disease

Bone
I Ross GarrettGregory R Mundy

Abstract

Myeloma causes a devastating and unique form of osteolytic bone disease. Although osteoclast activation is responsible for bone destruction, the precise mechanisms by which myeloma cells increase osteoclast activity have not been defined. An animal model of human myeloma bone disease would help in clarification of these mechanisms. Multiple myeloma occurs spontaneously in aging C57 BL/KaLwRij mice and has all of the features of the disease in humans, including the characteristic bone lesions. The disease can be induced in normal C57 BL/KaLwRij mice by inoculation of fresh marrow-derived cells from mice with myeloma, but this model is difficult to study because of variability in the number of myeloma cells in marrow-derived preparations. To develop a better animal model of human myeloma bone disease, we have established and subcloned a cell line from this murine myeloma and found that it causes osteolytic bone lesions in mice characteristic of human myeloma bone disease. The cell line produces interleukin-6, but grows independent of exogenous interleukin-6. Mice inoculated intravenously with the cultured cells predictably develop an identical disease to the mice injected intravenously with fresh bone-marrow-derived myeloma cells...Continue Reading

References

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Citations

Dec 19, 2008·International Journal of Hematology·Ken-Ichi KitazoeToshio Matsumoto
Sep 19, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G R Mundy
May 7, 2002·Nature Reviews. Cancer·W Michael Kuehl, P Leif Bergsagel
Jun 10, 2000·British Journal of Haematology·B O OyajobiS J Gao
Sep 26, 2009·Disease Models & Mechanisms·Jessica A FowlerClaire M Edwards
Apr 8, 2014·Biochemical Pharmacology·Eric SanchezJames R Berenson
Oct 9, 2015·Journal of Hematology & Oncology·Jacqueline E NollAndrew Cw Zannettino
Apr 23, 2015·Morphologie : Bulletin De L'Association Des Anatomistes·H Libouban
Aug 12, 2014·Biochimica Et Biophysica Acta·M BinsfeldJ Caers
Dec 26, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Robbert van der VoortHarry Dolstra
Apr 10, 2007·Cancer Cell·Daniel R CarrascoRonald A DePinho
Aug 15, 2014·Neoplasia : an International Journal for Oncology Research·Jacqueline E NollAndrew C W Zannettino
Nov 2, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Putthiporn CharoenphunPhilip J Blower
Oct 22, 2008·Biochemical and Biophysical Research Communications·Michelle A LawsonPeter I Croucher
Mar 6, 2013·The Journal of Infectious Diseases·Vanaja KonduriAmar Safdar
Mar 12, 1998·Endocrine Reviews·T A Guise, G R Mundy
Mar 21, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mahmoud AliMelissa L Bates
Jan 30, 2020·PloS One·Natasha FriendAndrew C W Zannettino

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