PMID: 9171119Jun 1, 1997Paper

A murine model of laparoscopic-assisted intervention

Surgical Endoscopy
J D AllendorfR L Whelan

Abstract

In order to better investigate the effects of laparoscopic surgery, it is necessary to establish reliable, reproducible, and economical animal models of laparoscopic intervention. Here we describe a mouse model of laparoscopic-assisted colon resection. After successful induction of anesthesia the mouse is placed in Trendelenburg position and the peritoneal cavity is insufflated with carbon dioxide gas through an angiocatheter placed in the right upper quadrant. A 4-mm rigid scope with camera attachment is then inserted through a midline port created just caudal to the xiphoid. A second port is then created in the right lower quadrant to allow introduction of laparoscopic forceps into the peritoneal cavity. The cecum, which extends 1.5 cm beyond the ileocecal valve, is grasped with forceps and exteriorized through the operative port. Extracorporeally, the cecum is ligated and resected before the cecal stump is returned to the peritoneal cavity. The abdominal wall defects are then stapled closed. This simple model can be mastered by individuals with very limited surgical experience. This laparoscopic model has been used successfully in our laboratory in a number of experiments with an intraoperative complication rate of 3. 2% (3/...Continue Reading

Citations

Apr 23, 2011·Surgical Endoscopy·Joshua R KarasRoberto Bergamaschi
Nov 24, 2004·The Journal of Surgical Research·Joseph M FuentesMark A Talamini
May 5, 1999·The Journal of the American Association of Gynecologic Laparoscopists·E HirschJ O Rosenberg
May 17, 2013·World Journal of Gastrointestinal Endoscopy·Ramon BartolíVicente Lorenzo-Zúñiga

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