A Murine Model of Myocardial Ischemia-Reperfusion Injury

Methods in Molecular Biology
Zhaobin XuNoah Weisleder

Abstract

Ligation of the left anterior descending (LAD) coronary artery in the mouse heart is a widely used model to simulate myocardial infarction and ischemia-reperfusion injury. Here we describe a ligation technique routinely performed in our laboratory to induce myocardial infarction that may be used to study ischemia-reperfusion injury in the myocardium. The methods described enhance location of the LAD coronary artery to allow for accurate ligation, thus increasing reproducibility of infarct size and location.

Citations

Apr 26, 2020·Journal of Cardiovascular Translational Research·Nana HeHonghua Ye
Aug 28, 2020·Biomolecules·Olga M RusieckaBrenda R Kwak
Feb 23, 2021·Signal Transduction and Targeted Therapy·Kang SunJin Jin

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