A muscle's force depends on the recruitment patterns of its fibers.

Annals of Biomedical Engineering
James M WakelingAndrew A Biewener

Abstract

Biomechanical models of whole muscles commonly used in simulations of musculoskeletal function and movement typically assume that the muscle generates force as a scaled-up muscle fiber. However, muscles are comprised of motor units that have different intrinsic properties and that can be activated at different times. This study tested whether a muscle model comprised of motor units that could be independently activated resulted in more accurate predictions of force than traditional Hill-type models. Forces predicted by the models were evaluated by direct comparison with the muscle forces measured in situ from the gastrocnemii in goats. The muscle was stimulated tetanically at a range of frequencies, muscle fiber strains were measured using sonomicrometry, and the activation patterns of the different types of motor unit were calculated from electromyographic recordings. Activation patterns were input into five different muscle models. Four models were traditional Hill-type models with different intrinsic speeds and fiber-type properties. The fifth model incorporated differential groups of fast and slow motor units. For all goats, muscles and stimulation frequencies the differential model resulted in the best predictions of muscl...Continue Reading

References

Dec 1, 1987·Journal of Muscle Research and Cell Motility·A J BullerK W Ranatunga
Oct 1, 1987·Journal of Neuroscience Methods·E Otten
Jan 1, 1987·Journal of Morphology·E Otten
Jan 1, 1973·Journal of the Neurological Sciences·M A JohnsonD Appleton
Jan 1, 1972·Physiological Reviews·R I Close
Jan 1, 1973·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M A ArianoV R Edgerton
Jul 1, 1974·Journal of Neurology, Neurosurgery, and Psychiatry·C A GillespieV R Edgerton
Nov 1, 1974·Journal of Neurophysiology·E HennemanR D Skinner
Oct 1, 1969·The Journal of Physiology·P M Rack, D R Westbury
May 15, 1965·Nature·R Close
Dec 1, 1984·IEEE Transactions on Bio-medical Engineering·M Solomonow
Jan 1, 1983·European Journal of Applied Physiology and Occupational Physiology·A A Vandervoort, A J McComas
Nov 1, 1994·Journal of Applied Physiology·B RoszekP A Huijing
Dec 1, 1993·Journal of Neurophysiology·A J FuglevandA E Patla
Jan 1, 1993·Biological cybernetics·A J van Soest, M F Bobbert
Aug 26, 2000·Progress in Biophysics and Molecular Biology·R Bottinelli, C Reggiani
Dec 5, 2000·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·V von Tscharner
Oct 17, 2002·Journal of Applied Physiology·Gary B Gillis, Andrew A Biewener
Oct 29, 2002·Muscle & Nerve·James M Wakeling, Douglas A Syme
May 15, 2003·Computer Methods in Biomechanics and Biomedical Engineering·Brian R UmbergerPhilip E Martin
Apr 27, 2004·The Journal of Experimental Biology·Luana TonioloFrancesco Mascarello
Oct 9, 2004·The Journal of Experimental Biology·James M Wakeling
Dec 6, 2005·The Journal of Experimental Biology·Gary B GillisAndrew A Biewener
Jul 20, 2006·Journal of the Royal Society, Interface·James M WakelingAntra I Rozitis
Jan 1, 1974·The Journal of Physiology·R I Close, A R Luff
Jun 19, 2007·The Journal of Experimental Biology·E F Hodson-Tole, J M Wakeling
Nov 22, 2007·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·James M Wakeling
Jun 3, 2008·The Journal of Experimental Biology·Emma F Hodson-Tole, James M Wakeling
Jun 3, 2008·The Journal of Experimental Biology·Emma F Hodson-Tole, James M Wakeling
Jul 4, 2008·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Emma F Hodson-Tole, James M Wakeling
Jun 16, 2009·The Journal of Experimental Biology·M Polly McGuiganAndrew A Biewener

❮ Previous
Next ❯

Citations

Mar 13, 2014·Journal of Biomechanics·D F B HaeufleS Schmitt
Apr 17, 2018·PLoS Computational Biology·Stephanie A RossJames M Wakeling
Jan 14, 2017·Journal of Neural Engineering·Chuanxin M NiuFrancisco J Valero-Cuevas
Feb 17, 2017·The Journal of Experimental Biology·Taylor J M DickJames M Wakeling
Nov 23, 2016·IEEE Transactions on Bio-medical Engineering·Antoine FalisseFriedl De Groote
Nov 23, 2018·Journal of the Royal Society, Interface·Adrian K M LaiJames M Wakeling
Jan 14, 2018·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Courtney P OrsbonCallum F Ross
Nov 23, 2019·The Journal of Experimental Biology·Carolyn M EngAndrew A Biewener
Oct 28, 2019·Medicine and Science in Sports and Exercise·Marlene GiandoliniBenno M Nigg
Jun 13, 2020·The Journal of Experimental Biology·Marissa A GorvetMichael T Butcher
Oct 24, 2017·Journal of Neuroengineering and Rehabilitation·Richard L LieberWalter Herzog
Jun 7, 2017·Biomechanics and Modeling in Mechanobiology·Lorenzo MarcucciPiero G Pavan
Sep 13, 2017·Journal of Neuroengineering and Rehabilitation·Andrew D NordinFay B Horak
Dec 6, 2020·Physiological Reports·Bryan R SchlinkDaniel P Ferris
Aug 2, 2020·The Journal of Experimental Biology·Stephanie A RossJames M Wakeling
Feb 6, 2021·Journal of Biomechanics·J M WakelingA A Biewener
May 14, 2021·Frontiers in Physiology·Gernot O Hering, Jens Stepan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved