A mutant cell in which association of class I heavy and light chains is induced by viral peptides

Cold Spring Harbor Symposia on Quantitative Biology
A TownsendK Kärre

Abstract

Association of the Db heavy chain with beta 2-microglobulin and expression of Db and Kb at the surface of the cell are induced by specific peptides in the mutant RMA-S. Association of antigenic peptides with the binding site of class I molecules may be required for correct folding of the heavy chain, association with beta 2-microglobulin, and transport of the antigen-MHC complex to the cell surface.

Citations

Jan 1, 1990·Immunogenetics·J M PickelM D Cooper
Jan 1, 1994·Molecular Aspects of Medicine·A MorrisS Young
Feb 1, 1993·Current Opinion in Immunology·H G RammenseeO Rötzschke
Oct 19, 1999·International Journal of Radiation Oncology, Biology, Physics·I F CiernikD P Carbone
Sep 5, 2013·Proceedings of the National Academy of Sciences of the United States of America·Sunil Kumar SainiSebastian Springer
Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·H J StaussC Sinclair
Nov 1, 1991·The Journal of Experimental Medicine·O RötzschkeH G Rammensee
Feb 1, 1992·The Journal of Experimental Medicine·L PazmanyA McMichael
Feb 6, 2013·PLoS Pathogens·Nathan P CroftAnthony W Purcell
May 18, 2000·Journal of Neuroimmunology·A CornetR S Liblau
Apr 15, 2006·International Journal of Cancer. Journal International Du Cancer·Liying ChenMikael Jondal
Jun 29, 2012·European Journal of Immunology·Elizabeth E CheneyMary A Markiewicz
Jul 27, 1990·Cell·A TownsendA Tse
Dec 3, 1999·Biochimica Et Biophysica Acta·R Abele, R Tampé
Apr 10, 2008·PloS One·Adam WasserstromEhud Shapiro
Sep 8, 2016·Proceedings of the National Academy of Sciences of the United States of America·Verena SchuetteSven Burgdorf
Apr 1, 1997·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·P A BedfordS C Knight
Jan 5, 2002·Physiological Reviews·Brigitte Lankat-Buttgereit, Robert Tampé
Jan 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mary A MarkiewiczAndrey S Shaw
Jun 24, 2008·Molecular Cancer Research : MCR·Md Imtaiyaz HassanFaizan Ahmad

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