A mutation at position 190 of human immunodeficiency virus type 1 reverse transcriptase interacts with mutations at positions 74 and 75 via the template primer.

Antimicrobial Agents and Chemotherapy
Paul L BoyerS H Hughes

Abstract

We have analyzed amino acid substitutions at position G190 in the reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1). The mutation G190E, which is responsible for resistance to certain nonnucleoside inhibitors, results in RT that has significantly less polymerase activity and that is less processive than wild-type RT. Its kinetic profile with respect to dGTP and poly(rC).oligo(dG) is significantly altered compared to that of wild-type RT. The combination of either of the mutations L74V or V75I with the G190E mutation appears to be compensatory and mitigates many of the deleterious effects of the G190E mutation.

References

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Citations

Mar 6, 1999·Current Opinion in Microbiology·J BalzariniE De Clercq
Jun 19, 2001·Virus Research·K M McGrathR Swanstrom
Aug 16, 2001·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Lee T. Bacheler
Oct 4, 2008·AIDS·Koen DeforcheUNKNOWN non-B Workgroup
Feb 27, 1999·Journal of Molecular Biology·P L BoyerS H Hughes
Mar 29, 2000·Proceedings of the National Academy of Sciences of the United States of America·P L BoyerS H Hughes
Jul 13, 2000·Reviews in Medical Virology·D PillayD D Richman
Mar 17, 2004·AIDS Research and Human Retroviruses·Maria G IsaguliantsBritta Wahren
Jun 23, 2004·Research in Microbiology·Sophie Maisnier-Patin, Dan I Andersson
Oct 7, 2004·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Erik J UhlmannMax Q Arens

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