A mutation in H5 haemagglutinin that conferred human receptor recognition is not maintained stably during duck passage.

The Journal of General Virology
Kyoko ShinyaYoshihiro Kawaoka

Abstract

A/Hong Kong/213/97 (HK213; H5N1), isolated from a human, binds to both avian- and human-type receptors, due to a haemagglutinin (HA) mutation probably acquired during adaptation to humans. Duck passage of this virus conferred lethality in ducks. Sequence analyses of the duck-passaged virus revealed that its HA gene reverted back to one recognizing only avian-type receptors, and consequently it bound human tissue to a lesser extent. This finding suggests that viruses with human-type receptor specificity are unlikely to be maintained in waterfowl, unlike those with the human-type PB2 mutation, such as H5N1 viruses of the Qinghai Lake lineage.

References

Aug 4, 1999·Proceedings of the National Academy of Sciences of the United States of America·G NeumannY Kawaoka
Jan 29, 2002·Archives of Virology·E HoffmannD R Perez
Feb 28, 2004·Lancet·J S M PeirisY Guan
Apr 14, 2004·Journal of Virology·Katharine M Sturm-RamirezRobert G Webster
Jul 15, 2005·Journal of Virology·Kyoko ShinyaYoshihiro Kawaoka
Oct 18, 2005·Virology·Alexandra GambaryanAlexander Klimov

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Citations

Apr 27, 2013·Virus Research·James C Paulson, Robert P de Vries
Jul 31, 2013·Comparative Immunology, Microbiology and Infectious Diseases·Eva MertensWalter M Boyce
Jan 23, 2020·Cold Spring Harbor Perspectives in Medicine·Dayan WangYuelong Shu

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Datasets Mentioned

BETA
AB212050
AB212052
AY576405
AB212054
AB212055
AB212056
AB212057
AB212058

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